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| Investigators showed that Apc-mutant intestinal stem cells (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable human intestinal epithelial cells (hIECs) progenitors and a functional hIEC monolayer exhibiting intestinal molecular features, cell type diversity, and high activities of intestinal transporters and metabolic enzymes such as cytochrome P450 3A4.
[Science Advances] |
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| Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays showed that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.
[Nature Communications] |
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| Investigators interrogated gene expression in separate microenvironments of glioblastoma organoid models that mimiced the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing.
[Acta Neuropathologica Communications] |
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| Three paired pancreatic ductal adenocarcinoma preclinical models-patient-derived xenografts, xenograft-derived pancreatic organoids and xenograft-derived primary cell cultures-were derived from 20 patients and analyzed at the transcriptomic and chemosensitivity level.
[Cancers] |
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| Differentiation of organoids significantly increased the expression of multiple cytochrome P450, phase II enzymes, liver biomarkers and hepatic transporters. The differentiated organoids were shown to exhibit increased sensitivity to midazolam and irinotecan, when compared to the undifferentiated organoids.
[Archives of Toxicology] |
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| The authors carried out high-throughput functional screening using impedancemetry, and identified five miRNAs with potential antiproliferative or chemosensitive effects on SW1353 chondrosarcoma cells.
[International Journal of Molecular Sciences] |
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| The impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively.
[Marine Drugs] |
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| Investigators described a novel in situ cryopreservation technology on the superhydrophobic microwell array chip-chip to preserve the viability of the organoids for future drug sensitivity tests.
[Micromachines] |
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| Scientists highlight the advantages and limits of patient-derived models as innovative and valuable pre-clinical tools to study progression and metastasis of colorectal cancer, develop novel therapeutic strategies by creating a drug screening platform, and predict the efficacy of clinical response to therapy.
[Journal of Experimental & Clinical Cancer Research] |
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| Recent advances in the field of organopalladium compounds as potential anticancer agents are discussed.
[Cell Reports Physical Science] |
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| Harvard University has granted an exclusive license to biotechnology company Obatala Sciences to commercialize innovations that enable the study of human fat tissue in vitro. Harvard Office of Technology Development and Obatala, which manufactures stem cell and hydrogel products to enable next-generation therapeutics discovery, announced the agreement.
[Harvard University] |
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| September 6 – 10, 2021
Virtual |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Uppsala University – Uppsala, Sweden |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Kings’s College London – London, England, United Kingdom |
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| | University of Maryland School of Medicine – Baltimore, Maryland , United States |
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