 | | Vol. 2.22 – 10 June, 2021 |
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| 3D vascularized pancreatic adenocarcinoma tissue was microengineered in a tri-culture system composed of patient-derived pancreatic organoids, human fibroblasts, and endothelial cells on a perfusable platform, situated in a 96-well plate.
[Advanced Functional Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
[Hepatology] |
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| The authors identified growth hormone receptor was mainly expressed in mesenchymal cells, and its expression was substantially decreased in idiopathic pulmonary fibrosis lungs.
[Science Advances] |
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| Scientists reported the generation of a hepatobiliary tubular organoid using mouse hepatocyte progenitors and cholangiocytes.
[Nature Communications] |
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| Researchers examined the ability of patient-derived organoids to predict clinical responses to targeted therapies in individual patients and to identify effective anti-cancer therapies for novel molecular targets.
[Clinical Cancer Research] |
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| The authors showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
[Oncogene] |
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| Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
[Ebiomedicine] |
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| Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet was positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience] |
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| Current approaches to bioprinting such implants fell into one of two categories, each with their own advantages and limitations. First are those that could be 3D bioprinted and then directly implanted into the body and second those that required further in vitro culture after bioprinting to engineer more mature tissues prior to implantation.
[iScience] |
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| The authors isolated basal cells from the rat epididymis and established 3-dimensional cell cultures from the basal and non-basal cell fractions. Organoids were formed by single adult epididymal basal cells.
[Biology of Reproduction] |
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| Upon treatment with N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine, a zinc chelator, organoids degenerated and its negative effect was rescued by co-treatment with zinc, indicating that zinc was necessary for the growth and survival of tumor organoids.
[Biological Trace Element Research] |
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| The authors discuss the potential of “organ-on-a-chip” systems to study regenerative therapies with focus on three distinct organ systems: cardiac, respiratory, and hematopoietic.
[Cell Stem Cell] |
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| Investigators review recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models.
[Cell Host & Microbe] |
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| The molecular networks that activate in cells in response to mechanical stimuli are yet not well-understood. The limited knowledge stems partially from the lack of available tools that are capable of exerting controlled mechanical stress to individual cells and at the same time observing their responses at subcellular to molecular resolution.
[Journal of Applied Physics] |
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| An official opening ceremony for the Hub will take place once it is permissible to do so. For the first Hub program – research into organoid models – Dr. Kai Wicker and his team have moved into the EKFZ for Digital Health on the campus of the Carl Gustav Carus University Hospital – a stone’s throw away from top experts in the field.
[Technische Universität Dresden (EurekAlert!)] |
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| Laura Pellegrini, a postdoc in Madeline Lancaster’s group in the LMB’s Cell Biology Division, has been awarded the 2020 3Rs Prize for her paper ‘Human CNS barrier-forming organoids with cerebrospinal fluid production’, which was published in Science last July.
[MCR Laboratory of Molecular Biology] |
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| September 13 – 15, 2021
Virtual |
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| | BioMed X Research Institute – Heidelberg, Germany |
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| | GSK – San Francisco, California, United States |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Uppsala University – Uppsala, Sweden |
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| | Kings’s College London – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
