 | | Vol. 2.23 – 17 June, 2021 |
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| Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the generation of an expandable, 3D branching ureteric bud (UB) organoid culture model that could be derived from primary UB progenitors from mouse and human fetal kidneys, or generated de novo from human PSCs.
[Nature Communications] |
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| Scientists examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids.
[Journal of Experimental Medicine] |
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| By targeting antiapoptotic proteins with specific BH3 mimetics in organoid models of colorectal cancer progression, scientists found that BCL-2 was essential only during instestinal stem cell transformation while MCL1 inhibition did not affect adenoma outgrowth.
[Cell Death & Differentiation] |
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| Scientists developed an impedance system to measure the change in electrical resistance of 3D human-iPSC-derived intestinal organoids depending on the integrity of the intestinal epithelial cell membrane, which could reflect functionality and maturity.
[Analytical Chemistry] |
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| Using ex vivo cell models, investigators analyzed SARS-Cov2 interactions with kidney tubular cells and assessed direct tubular injury. These models comprised primary human kidney epithelial cells and more quiescent three-dimensional kidney spheroids.
[Clinical Journal of the American Society of Nephrology] |
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| Retinal organoids were generated and organized into an in vitro assembloid model of the visual system with cortical and thalamic organoids.
[Stem Cell Reports] |
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| A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy] |
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| The authors presented an alternative technique based on deriving organoids from menstrual flow. They demonstrated that organoids could be derived from gland fragments recovered from menstrual flow.
[Communications Biology] |
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| Investigators discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organizing cultures, or by controlled assembly through microfluidic and print-based technologies.
[Communications Biology] |
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| Scientists provide highlights on the development of organoid technology, and the use of this culture system to study the pathophysiology of specific mutations in the development of pancreatic and gastric cancer.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The Canadian federal government announced more than 150 new and renewed Canada Research Chairs (CRCs) at institutions across the country. Dr. Jack Chu’s successful CRC Tier II application focused on using stem cells to model human and animal developmental clocks and related disorders.
[University of Calgary] |
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| The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
[Columbia University Irving Medical Center] |
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| August 22 – 25, 2021
Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | BioMed X Research Institute – Heidelberg, Germany |
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| | GSK – San Francisco, California, United States |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Uppsala University – Uppsala, Sweden |
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