 | | Vol. 2.24 – 24 June, 2021 |
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| Scientists mapped 3D cellular forces in mouse intestinal organoids grown on soft hydrogels and showed that these organoids exhibit a non-monotonic stress distribution that defined mechanical and functional compartments.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| SARS-CoV-2-infected cells showed accumulation of key metabolites, activation of autophagy inhibitors and reduction of proteins responsible for autophagy initiation, membrane nucleation, and phagophore formation, as well as autophagosome-lysosome fusion.
[Nature Communications] |
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| Using cell models from systematic ECM screen to collagen-based 2D and 3D cultures, the authors demonstrated that both specific ECM substrates and stiffness increased resistance to platinum-mediated, apoptosis-inducing DNA damage via FAK and β1 integrin-pMLC-YAP signaling.
[Nature Communications] |
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| A magnetically powered stem cell-based microrobot (“Cellbot”) was used for minimally invasive targeted stem cell delivery to the brain through the intranasal passage. Using an ex vivo model based on brain organoids, it was determined that the Cellbots could be transplanted into brain tissue.
[Advanced Healthcare Materials] |
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| The authors observed that UCA1 a lncRNA previously reported to play an oncogenic role in several malignancies, was overexpressed in the chemoresistant ovarian cancer cell line OAW42-R compared to their chemotherapy sensitive counterpart OAW42.
[Molecular Oncology] |
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| Scientists reported an organoid model of neural tube extension derived from human human PSC aggregates that had been caudalized with Wnt agonism, enabling them to recapitulate aspects of the morphological and temporal gene expression patterns of neural tube development.
[Development] |
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| Well-established 3D organoid models of human colon and small intestine were used to characterize 5-Fluorouracil (5-FU) transcriptomic and metabolomic responses. Based on analysis of the differentially expressed genes, the most prominent molecular pathways affected by 5-FU included cell cycle, p53 signaling, mitochondrial ATP synthesis and apoptosis.
[Archives of Toxicology] |
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| The authors employed a robust method, without the need for mouse co-culture to generate 3D cerebellar organoids from human PSCs that displayed hallmarks of in vivo cerebellar development.
[Scientific Reports] |
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| Investigators developed a human-on-a-chip model composed of human hepatocytes and adipose tissue chambers capable of modeling the metabolic factors that contribute to liver disease development and progression, and evaluation of the therapeutic metformin.
[Scientific Reports] |
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| Researchers mechanically cut 70-day-old human PSC-derived cerebral organoids (HCOs) with a scalpel blade into two to four pieces, each depending on their original size. After culturing cut hCOs for additional seven days, their size was less variable and smaller than uncut hCOs and there were no histological differences between uncut and cut hCOs.
[Heliyon] |
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| Scientists focus on engineering approaches for building tumor organoids, including biomaterial-based, microfabrication-assisted, and synthetic biology-facilitated strategies.
[Advanced Drug Delivery Reviews] |
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| Tessa Therapeutics Ltd. announced a collaboration agreement with the Agency for Science Technology and Research’s (A*STAR) Institute of Molecular and Cell Biology (IMCB) in Singapore to form a research laboratory. The collaboration is focused on IMCB’s research expertise, including new humanized patient-derived-xenograft and patient-derived-organoid models.
[Tessa Therapeutics Ltd.] |
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| NovoBiome announced that its building NovoSif®, a disruptive ex vivo research and discovery platform to analyze the symbiotic relationship between the microbiota and the human intestine.
[NovoBiome (GlobeNewswire, Inc.)] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | University of Basel – Basel, Switzerland |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | BioMed X Research Institute – Heidelberg, Germany |
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| University of Cambridge – Cambridge, England, United Kingdom |
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