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| Using patient-derived colorectal cancer organoids and fresh tumor biopsies, the authors demonstrated that karyotype alterations of varying complexity were prevalent and could arise within a few cell generations.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using junctional adhesion molecules (JAM)-A knockdown, re-expression and rescue experiments in cell line monolayers, 3D spheroids, patient-derived organoids and xenotransplants, researchers demonstrated that JAM-A silencing promoted proliferation and migration in 2D and 3D cell models and increased tumor volume and metastases in vivo.
[Cell Death & Differentiation] |
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| The authors described a protocol that could be used to coculture a primary human colon monolayer with aerotolerant bacteria. Primary human colon cells maintained as organoids were dispersed into single-cell suspensions and then seeded on collagen-coated Transwell inserts, where they attached and proliferated to form confluent monolayers within days of seeding.
[Nature Protocols] |
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| Patient tumor organoids were fabricated using unsorted tumor cells with and without enrichment with patient matched immune components derived from peripheral blood leukocytes, spleen, or lymph nodes.
[Clinical Cancer Research] |
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| Scientists showed that cancer cells used competitive cell interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosted proliferation of intestinal cancer cells.
[Cell Reports] |
| | Investigators found that in KrasG12D-expressing endometrial organoids, Pten knockdown did not confer tumorigenicity, but Cdkn2a knockdown or Trp53 deletion led to the development of carcinosarcoma, a rare, aggressive tumor comprising both carcinoma and sarcoma.
[Oncogenesis] |
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| Florescence-activated flow cytometry analysis, immunofluorescence and organoid culture system were performed to identify the β-catenin/Wnt-activated cells in Fam13a+/+ or Fam13a−/− mice exposed to ciagrette smoke.
[Ebiomedicine] |
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| With a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, investigators found that specific CD8+ T cell responses were identified in over 75% of COVID-19 convalescent patients
[Genes & Diseases] |
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| The authors reported that porcine enteroids responded in a similar manner as in vivo gut tissues to enterotoxins derived from enterotoxigenic Escherichia coli, an enteric pathogen causing postweaning diarrhea in piglets.
[Veterinary Research] |
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| Investigators developed a potent inhibitor of cyclin-dependent kinase 7 (CDK7), designated YPN-005, and determined whether it showed any anticancer effects in small cell lung cancer (SCLC), cells, cisplatin or etoposide-resistant cells, or organoids derived from SCLC patients.
[European Journal of Pharmacology] |
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| Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. The authors describe both normal and CRC intestinal organoid models and their utility in the cancer research field.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| MIMETAS, a developer of organ-on-chip-based disease models, and Roche announced that they have entered into a collaboration to develop human disease models to characterize novel compounds in inflammatory bowel disease and hepatitis B virus infections.
[MIMETAS] |
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| Researchers from the University of Sydney have been awarded $6.3 million for three projects which will address stem cell derived-retinal organoids for blindness in adults, iPSC derived cardiomyocytes for chronic heart failure, and help to improve decisions about access to stem cell interventions.
[The University of Sydney] |
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| August 23 – September 2, 2021
Virtual |
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| | North Carolina A&T State University – Greensboro, North Carolina, United States |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | The European Molecular Biology Laboratory – Barcelona, Spain |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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