 | | Vol. 2.26 – 15 July, 2021 |
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| Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Scientists showed that pericyte-like cells, when integrated into a cortical organoid, were capable of infection with authentic SARS-CoV-2.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the single-cell characterization of the differentiation of pancreatic duct-like organoids from human induced pluripotent stem cells (hiPSCs) on a microwell chip that facilitated the uniform aggregation and chemical induction of hiPSC-derived pancreatic progenitors.
[Nature Biomedical Engineering] |
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| Scientists reported that cells derived from claudin-low mammary tumors, a mesenchymal subtype of triple-negative breast cancer, exhibited a distinctive organoid structure with extended “spikes” in 3D matrices.
[Nature Communications] |
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| The authors identified a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 and environmental exposure to an organophosphate pesticide an iPSC-derived human 3D brain model.
[Experimental Health Perspectives] |
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| Scientists showed that cancer cells used competitive cell interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosted proliferation of intestinal cancer cells.
[Cell Reports] |
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| Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.
[Cell Reports] |
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| To overcome limitations and address species-specific cellular organization, the authors derived organoids from rapidly developing teleosts.
[eLife] |
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| Investigators developed a patient-derived colorectal cancer organoid model and performed pairwise analysis of 87 colorectal cancer organoids and their matched primary tumors. The tumor immune microenvironment type of the primary tumor was classified as immuno-active, immuno-exhausted, or immuno-desert.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors review the current achievements in brain organoid biology and their relevance to HIV infection of the brain (neuroHIV) research efforts.
[mBio] |
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| Scientists presented an in vitro functional precision medicine assay which enabled the study of tumouroid induced angiogenesis.
[PLoS One] |
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| Cholangiocytes were collected from intrahepatic bile ducts, gallbladder, and crypts from the small intestine using gravity settling and multi-step centrifugation methods, and embedded in Matrigel to grow into 3D spheroids in suitable culture medium.
[Military Medical Research] |
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| The authors review the major developments in ovarian cancer, including genetics, model systems and technologies available for their study and the implications of applying epigenetic therapies to ovarian cancer.
[International Journal of Cancer] |
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| Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures.
[Macromolecular Bioscience] |
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| ExCellThera, Inc. announced that it has entered into a licensing agreement with Astellas Pharma, Inc. through its US subsidiary, Astellas Institute for Regenerative Medicine, for the in vitro use of the UM171 compound and certain other molecules in the field of PSCs and PSC-derived cells.
[ExCellThera, Inc.] |
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| Vyant Bio, Inc. announced that its wholly-owned subsidiary, StemoniX, Inc. was issued US Patent No. 11054408, titled “High Throughput Optical Assay of Human Mixed Cell Population Spheroids” by the United States Patent and Trademark Office.
[Vyant Bio, Inc.] |
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| September 24 – 27, 2021
Kloster Seeon, Germany |
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| | GSK – Moon Township, Pennsylvania, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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Cancer Stem Cell News
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