Organoid News Volume 2.27 | Jul 22 2021

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    2021-07-22 | ON 2.27


    Organoid News by STEMCELL Technologies
    Vol. 2.27 – 22 July, 2021
    TOP STORY

    PGD2 and CRTH2 Counteract Type 2 Cytokine–Elicited Intestinal Epithelial Responses during Helminth Infection

    Researchers showed that mice deficient in the prostaglandin D2 receptor CRTH2 and mice with CRTH2 deficiency only in nonhematopoietic cells exhibited enhanced worm clearance and intestinal goblet cell hyperplasia following infection with the helminth Nippostrongylus brasiliensis.
    [Journal of Experimental Medicine]

    Full Article

    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    PUBLICATIONSRanked by the impact factor of the journal

    Telomere Dysfunction Instigates Inflammation in Inflammatory Bowel Disease

    In murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) resulted in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which in turn up-regulated pro-IL-18, a pivotal immune regulator in inflammatory bowel disease pathogenesis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Modeling Genetic Epileptic Encephalopathies Using Brain Organoids

    The authors generated an in vitro model for developmental and epileptic encephalopathies, using the devastating WW domain-containing oxidoreductase-related epileptic encephalopathy syndrome as a prototype, by establishing brain organoids from CRISPR-engineered human ES cells and from patient-derived induced pluripotent stem cells.
    [EMBO Molecular Medicine]

    Full Article

    Early Invasion of the Bladder Wall by Solitary Bacteria Protects UPEC from Antibiotics and Neutrophil Swarms in an Organoid Model

    Bacteria injected into the organoid lumen entered umbrella-like cells and proliferated to form intracellular bacterial communities-like bodies.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Modeling Alcohol-Associated Liver Disease in a Human Liver-Chip

    Investigators leveraged a triculture human Liver-Chip with biomimetic hepatic sinusoids and bile canaliculi to model alcohol-associated liver disease employing human-relevant blood alcohol concentrations and multimodal profiling of clinically relevant endpoints.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Establishment of Oxaliplatin-Resistant Gastric Cancer Organoids: Importance of Myoferlin in the Acquisition of Oxaliplatin Resistance

    Researchers established oxaliplatin resistant gastric cancer organoids and evaluated their gene expression profile using microarray analysis.
    [Gastric Cancer]

    Abstract

    Immuno-Genomic Classification of Colorectal Cancer Organoids Reveals Cancer Cells with Intrinsic Immunogenic Properties Associated with Patient Survival

    Scientists developed a patient-derived colorectal cancer organoid (CCO) model and performed pairwise analysis of 87 CCOs and their matched primary tumors. The tumor immune microenvironment type of the primary tumor was classified as immuno-active, immuno-exhausted, or immuno-desert.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Human Neuromuscular Junction Three-Dimensional Organoid Models and the Insight in Motor Disorders

    The authors introduced the most recent advances of human embryonic stem cell- or induced pluripotent stem cell-derived organoids to model 3D neuromuscular junctions.
    [Journal of Molecular Cell Biology]

    AbstractFull Article
    Graphical Abstract

    Use of Human Tissue Stem Cell-Derived Organoid Cultures to Model Enterohepatic Circulation

    Researchers demonstrated that mature stem cell-derived intestinal and liver organoid cultures each express functional molecules that modulate bile acid uptake and recycling.
    [American Journal of Physiology-Gastrointestinal and Liver Physiology]

    Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Extracellular Matrix Requirements for Gastrointestinal Organoid Cultures

    Investigators discuss the importance of the extracellular matrix (ECM) in intestinal, hepatic, and pancreatic organoid culture and how biomaterial-based approaches can be used to probe different ECM properties required for more physiologically and translationally relevant organoid models.
    [Biomaterials]

    Full Article

    Airway and Alveoli Organoids as Valuable Research Tools in COVID-19

    Human lung organoids can provide robust support to simulate SARS-CoV-2 infection and replication and aid in a better understanding of their effects in human tissue.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    State Gives $51 Million to College Students for Stem Cell Research

    The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
    [Capitol Weekly]

    Press Release
    FEATURED EVENT

    CRISPR and Beyond: Perturbations at Scale to Understand Genomes

    September 22 – 25, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Manager – Organoid Core Facility

    Weill Cornell Medicine – New York, New York, United States

    Research Scientist – Human Intestinal Organoids

    Stanford University – Palo Alto, California, United States

    Postdoctoral Fellow – Retinal Differentiation

    Albert Einstein College of Medicine – New York, New York, United States

    Postdoctoral Researcher – Stem Cells, Organoids, and Systems Biology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    PhD Student – Organotypic Models to Dissect the Cellular Crosstalk between Niche and HSPCs in Myelodysplastic Syndromes

    Georg-Speyer-Haus – Frankfurt, Germany

    > See All Jobs

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