 | | Vol. 2.28 – 29 July, 2021 |
| |
|
|
| Scientists used human induced pluripotent stem cell-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations because of the mutation that precede neurodegeneration.
[Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| IFITM-derived peptides and targeting antibodies inhibited SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids.
[Nature Communications] |
|
|
|
| Mouse and porcine retinas were decellularized and the protein profile analyzed. Acellular retinal extracellular matrix scaffolds were then repopulated with human iPSC-derived retinal pigment epithelial cells or ocular progenitor cells to assess their integration, proliferation and organization.
[Biomaterials] |
|
|
|
| Using mouse in utero electroporation technique and in vitro human neural stem cell (NSC) differentiation models including cerebral organoids, investigators showed that regulator of cell cycle modulated NSC self-renewal and neuronal differentiation by affecting cell cycle regulation and spindle orientation.
[EMBO Journal] |
|
|
|
| Scientists described a robust pan-cancer tumor organoids platform with chemically defined media optimized on cultures acquired from over 1,000 patients.
[Cell Reports] |
|
|
|
| Investigators developed a framework combining single-cell RNA-Seq and highly multiplex RNA FISH and applied it to human intestinal organoids infected with human astrovirus, a model human enteric virus.
[EMBO Reports] |
|
|
|
| The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.
[Science of the Total Environment] |
|
|
|
| Researchers reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.
[Stem Cell Reports] |
|
|
|
| Scientists devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contained human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.
[Cell and Tissue Research] |
|
|
|
|
| Investigators consider how mouse models can refine the understanding of the underlying biological and molecular processes that promote metastasis, and they envisage how the application of new technologies will further enhance investigations of metastasis at single-cell resolution in the context of the whole organism.
[Trends in Cancer] |
|
|
|
|
| LSI Director Dr. Josef Penninger and Drs. David Long, Luigi Gnudi, and Karen Price in the UK are recipients of a UK-Canada Diabetes Research Team Grant entitled “Bridging the gap to translation by understanding and preventing diabetic vascular complications using human organoid culture” as part of the 100 Years of Insulin initiative.
[The University of British Columbia] |
|
|
|
| Around 19 million people have been diagnosed with the disease and that figure is expected to rise dramatically over the next two decades. Tricia Larose from the University of Oslo believes the answer might lie in space. She’s the lead scientist of Tumors In Space- a research experiment that’s carrying human organoids to China’s Tiangong space station in 2025 to find out if cosmic radiation is a key cause of cancer.
[CGTN] |
|
|
|
|
| October 27 – 29, 2021
Virtual |
|
|
|
|
|
| Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
| | | King’s College London – London, England, United States |
|
|
|
| | Weill Cornell Medicine – New York, New York, United States |
|
|
|
| | Albert Einstein College of Medicine – New York, New York, United States |
|
|
|
| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
