 | | Vol. 2.29 – 5 August, 2021 |
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| Because the blood–brain barrier (BBB) leakage is a well-known risk factor for Alzheimer’s disease (AD), brain organoids were exposed to human serum to mimic the serum exposure consequence of BBB breakdown in AD patient brains.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers described the procedure and outcomes of human iPSC-derived retinal sheet transplantation in primate models using biodegradable materials.
[Acta Biomaterialia] |
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| The authors described a primary ex vivo hepatitis B virus (HBV)-infection model derived from healthy donor liver organoids after challenge with recombinant virus or HBV-infected patient serum.
[eLife] |
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| Investigators showed that human cortical neurons, derived from human pluripotent stem cells in 2D cultures or in cortical organoids, developed the typical hallmarks of senescent cells when maintained in vitro for prolonged periods of time, and that moderated upregulation or repression of endogenous Klotho expression in cortical organoids inhibited and accelerated senescence, respectively.
[npj Aging and Mechanisms of Disease] |
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| Scientists showed that Ogt was highly expressed in embryonic brain, and Ogt depletion reduced the proliferation of embryonic neural stem cells and migration of new born neurons.
[Human Molecular Genetics] |
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| The authors utilized an intestinal organoid approach to compare in vitro responses to two CFTR modulator drug combinations and to check potential inter-individual variability in therapeutic response to the triple combination.
[Journal of Cystic Fibrosis] |
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| Researchers evaluated the proapoptotic and antifibrotic efficacy of several classes of BH-3 mimetics in two in vitro fibrogenesis models. The candidate molecule, ABT-263, was advanced to a 3D human intestinal organoid model.
[Inflammatory Bowel Diseases] |
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| Investigators established in vitro paclitaxel-resistant ovarian cancer cell line and organoid models. Gene expression differences in resistant and sensitive lines were analyzed by RNA sequencing.
[PLoS One] |
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| Erythroid progenitors were reprogrammed by an episomal vector into iPSCs, which were differentiated into renal tubular organoids and then stimulated by forskolin to induce cysts formation.
[PLoS One] |
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| Scientists review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modeling of COVID-19 disease pathology and in drug, antibody and vaccine development.
[Nature Cell Biology] |
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| Investigators discuss how human pluripotent stem cells have brought, and may continue to bring, major changes to the field of respiratory diseases by understanding the molecular mechanisms of the pathology and by finding efficient therapeutics.
[European Respiratory Review] |
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| Monash epilepsy researchers are on an Medical Research Future Fund (MRFF) grant to personalise epilepsy anti-seizure treatment with brain organoids and artificial intelligence. Enabling innovative research that cuts across multiple scientific and clinical disciplines in order to address urgent unmet health care needs is what the MRFF scheme was designed to do, and is doing exactly that with its recently announced funding for a project to help patients with epilepsy.
[Monash University] |
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| Yogita K Adlakha, an Inspire Faculty Fellow, has developed human-based models to study neuron development and neurodevelopmental disorders such as autism, which can help design treatment strategies for such brain disorders, the Department of Science and Technology said.
[Outlook India] |
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| October 6 – 8, 2021
Online and Badalona, Spain |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | MSH Medical School Hamburg – Hamburg, Germany |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | King’s College London – London, England, United States |
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