 | | Vol. 2.30 – 12 August, 2021 |
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| The authors used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated two engineering elements to improve human brain organoid culture including a human brain extracellular matrix to provide brain-specific cues and a microfluidic device with periodic flow to improve the survival and reduce the variability of organoids.
[Nature Communications] |
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| Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.
[Nature Communications] |
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| Scientists provided detailed protocols for characterizing the coculture with regard to bacterial and organoid cell viability and growth kinetics and discussed considerations for assessing the impact of bacteria on gene expression and mutations through RNA and DNA sequencing.
[Nature Protocols] |
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| The authors showed, using prostate as a model tissue, that primary organoids and freshly isolated epithelial cells could be CRISPR edited ex vivo using Cas9-sgRNA ribotnucleoprotein complex technology, then orthotopically transferred in vivo into immunocompetent or immunodeficient mice to generate cancer models with phenotypes resembling those seen in traditional genetically engineered mouse models.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Mouse intestinal organoids and dextran sulfate sodium-induced colitis mouse model were used to assess the effects of recombinant soluble thrombomodulin on proliferation of intestinal epithelial cells.
[Clinical Gastroenterology and Hepatology] |
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| After generation of the bioscaffold, seeding of discoid scaffolds with trans-differentiated human hepatocyte-like cells was performed. Then, the generated organoid was implanted into peritoneal cavity or subcutaneous tissue of experimental rats.
[Stem Cell Research & Therapy] |
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| Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns, and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells were 3D-expanded, whereas cells from BT were expanded in 3D and 2D.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| The authors explored the use of prime editing in human organoids. Common TP53 mutations can be correctly modeled in human adult stem cell–derived colonic organoids with efficiencies up to 25% and up to 97% in hepatocyte organoids.
[Life Science Alliance] |
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| Investigators discuss the advantages and limitations of conventional models of the human auditory system, describe the generation and characteristics of PSC-derived inner ear organoids, and discuss several strategies and recent attempts to model hereditary deafness in vitro.
[Human Genetics] |
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| Scientists discuss the advantages and key limitations of the Alzheimer’s disease (AD) cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research.
[Translational Neurodegeneration] |
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| Based on the results of a bibliometric analysis of intestinal organoid applications, the authors systematically summarized the latest advances and analyzed the limitations and prospects.
[Frontiers in Cell and Developmental Biology] |
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| Researchers from the University of Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine and Carnegie Mellon University’s Computational Biology Department have been awarded almost $1.5 million from the National Science Foundation to develop new approaches for producing liver organoids -tiny, lab-grown human organs that have potential for disease modeling, drug discovery and transplantation.
[Univeristy of Pittsburgh Medicine] |
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| October 21 – 24, 2021
Portland, Oregon, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Philipps University of Marburg – Marburg, Germany |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| MSH Medical School Hamburg – Hamburg, Germany |
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| | Harvard Medical School​ – Boston, Massachusetts, United States |
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