 | | Vol. 2.31 – 19 August, 2021 |
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| A combination of single-cell transcriptomic profiling, in silico lineage tracing from methylation, open chromatin and somatic mutation analyses, and functional studies in organoid models showed that Barrett’s esophagus originated from gastric cardia through c-MYC and HNF4A-driven transcriptional programs.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Around day 30, brain organoids attempted to assemble optic vesicles, which developed progressively as visible structures within 60 days. These optic vesicle-containing brain organoids constituted a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.
[Cell Stem Cell] |
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| Scientists investigated the mechanisms linked to abnormal cholangiocyte development. They generated biliary organoids from liver biopsies of infants with biliary atresia and normal- and diseased-controls.
[Hepatology] |
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| To examine cellular spatiotemporal activity, researchers developed eveloped Spatially PhotoActivatable Color Encoded Cell Address Tags to annotate, track, and isolate cells while preserving viability.
[Nature Communications] |
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| Investigators showed that endoplasmic reticulum stress contributed to intestinal tissue injury during graft-versus-host disease and could be targeted pharmacologically.
[Haematologica] |
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| Human PSCs-L1 were differentiated to islet organoids and labeled with superparamagnetic iron oxide nanoparticles. The phantoms comprising of different numbers of labeled islet organoids were imaged using an magnetic particle imaging system.
[Nature Materials] |
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| The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| The authors presented a methodology for direct differentiation of the CRISPR-targeted cell pools, using a doxycycline-inducible Cas9 expressing human iPSC line for high efficiency editing to eliminate the laborious clonal line generation steps.
[Scientific Reports] |
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| Large clones were found between cartilage and smooth muscle where subpopulation of dorsal basal cells (BCs) existed. 3D organoid culture of BCs demonstrated that dorsal BCs showed higher colony forming efficacy to ventral BCs.
[Biology Open] |
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| Investigators describe the current challenges and recent multidisciplinary advancements and opportunities for standardizing next-generation cancer organoid systems.
[Nature Materials] |
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| Because the functional activity of neural cells within brain organoids relies on cell repertoire and time in culture, scientists review data supporting the gradual formation of complex neural networks in light of cell maturity within brain organoids.
[Frontiers in Neuroscience] |
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| STEMCELL Technologies and Hubrecht Organoid Technology announced that they have signed an agreement for the use of tissue-derived organoids—including lung, intestinal, and liver organoids—for use in preclinical toxicology screening and non-cancer drug development services to be offered by the Contract Assay Services division of STEMCELL.
[STEMCELL Technologies, Inc.] |
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| Vyant Bio, Inc. and Cyclica, Inc. announced a non-exclusive strategic collaboration combining Vyant Bio’s patient-derived complex organoid biology alongside Cyclica’s proteome-wide, Artificial Intelligence enabled discovery platform to identify new treatments for CDKL5 Deficiency Disorder, a severe neurodevelopmental epilepsy disorder with no effective treatments or cure.
[Vyant Bio, Inc.] |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Philipps University of Marburg – Marburg, Germany |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| MSH Medical School Hamburg – Hamburg, Germany |
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