 | | Vol. 2.32 – 26 August, 2021 |
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| Researchers developed a fragile X syndrome human forebrain organoid model and observed that the loss of fragile X mental retardation protein led to dysregulated neurogenesis, neuronal maturation, and neuronal excitability.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated highly abnormal and epileptiform-like activity in organoids derived from iPSCs from individuals with Rett syndrome,
[Nature Neuroscience] |
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| Investigators generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varients to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.
[Molecular Psychiatry] |
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| The authors reported a method to generate developmentally relevant human heart organoids by self-assembly using human PSCs. Heart organoids were comparable to age-matched human fetal cardiac tissues at the transcriptomic, structural, and cellular level.
[Nature Communications] |
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| REST inhibition promoted endocrinogenesis in zebrafish and mouse early postnatal ducts and induced β-cell-specific genes in human adult duct-derived organoids.
[Genes & Development] |
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| Anti-carcinogenic properties of amorphous curcumin, a compound with improved solubility and bioavailability, were evaluated against human colorectal cancer organoids.
[Biomedicine & Pharmacotherapy] |
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| To uncover the function of melatonin in Inflammatory bowel diseases, three intestinal models, including Caco-2 cells, 3D intestinal organoids and intestinal explants, were used.
[inflammopharmacology] |
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| 3D Organoids were grown in an extracellular matrix and characterized by qPCR. Organoids were also seeded on permeable filter supports in order to generate 2D epithelial monolayers.
[PLoS One] |
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| Scientists demonstrated that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase, pyrrolysyl-tRNA and the target protein of interest enables site-specific incorporation of a non-canonical amino acid in response to amber stop codons.
[Chembiochem] |
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| The authors describe the main applications of retinal organoids and provide a comprehensive overview of the state-of-art analysis methods that apply to this model system.
[Cellular and Molecular Life Sciences] |
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| Because the functional activity of neural cells within brain organoids relies on cell repertoire and time in culture, investigators review data supporting the gradual formation of complex neural networks in light of cell maturity within brain organoids.
[Frontiers in Neuroscience] |
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| Yu Huang, assistant professor of biological engineering, will receive $1.8 million from the National Institutes of Health to study cerebral morphology. Their goal is to better understand how a brain develops under spatial constraint and to uncover new insights into the spreading of brain cancer.
[Utah State University] |
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| September 28 – 29, 2021
Virtual |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Philipps University of Marburg – Marburg, Germany |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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