 | | Vol. 2.33 – 2 September, 2021 |
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| The authors provide an overview of state-of-the-art studies, challenges that have not yet been overcome and perspectives on cardiac tissue engineering.
[Nature Reviews Cardiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using human iPSC-derived cerebral organoid models, scientists found that APOE deletion increased α-synuclein accumulation accompanied with synaptic loss, reduction of GBA levels, lipid droplet accumulation and dysregulation of intracellular organelles.
[Acta Neuropathologica] |
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| Investigators performed drug screening on patient-derived normal and tumor organoids to identify malignant rhabdoid tumors-specific therapeutic vulnerabilities.
[Cell Reports] |
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| Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.
[Aging Cell] |
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| Researchers investigated donor-to-donor variability in human gut adult stem cell organoids. They examined intestinal developmental pathways during culture differentiation in ileum- and colon-derived cultures established from multiple donors, showing that differentiation patterns were consistent among cultures.
[Stem Cell Reports] |
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| Scientists developed a human kidney organoid model for Wilms tumor formation and show that deletion of WT1 during organoid development induced overgrowth of kidney progenitor cells at the expense of differentiating glomeruli and tubules.
[Stem Cell Reports] |
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| Investigators presented an experimental model for human luminal progenitor cells that enabled single, primary cells isolated from normal tissue to generate complex branched structures resembling the ductal morphology of low-grade carcinoma of no special type.
[Journal of Pathology] |
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| The authors generated a human brain organoid model of increased PTEN dosage. They showed that mild PTEN overexpression led to reduced neural precursor proliferation, premature neuronal differentiation, and the formation of significantly smaller brain organoids.
[Molecular Brain] |
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| Tumor organoids were developed ex vivo from freshly resected renal cell carcinoma tumors, and their histopathological and molecular characteristics were evaluated using histological staining and whole‑exome sequencing.
[Oncology Reports] |
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| A 3D thermo-reversible gelation polymer culture system was established for organoid culture of mouse fallopian tube epithelial stem cells without cell isolation.
[Tissue and Cell] |
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| Looking back, investigators discuss the key developments of this emerging technology. Thinking forward, they focus on the challenges faced to fully establish, validate, and utilize the fidelity of these models for biological research.
[Cell] |
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| Scientists discuss state-of-the-art lung, liver and kidney 3D organoid system utilizing the adverse outcome pathways to study SARS-CoV-2 molecular pathogenesis.
[Journal of Molecular Biology] |
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| Investigators summarized the different ionization methods, sample preparation steps and data analysis methods of mass spectrometry imaging (MSI) and focuses on several of the latest applications of matrix-assisted laser desorption/ionization MSI for drug studies in spheroids and organoids.
[Journal of Biological Chemistry] |
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| KangStem Biotech has signed a deal with Seoul National University’s R&DB Foundation to receive the university’s skin organoid manufacturing technology. The technology uses a 3D air-liquid interface skin organoid preparation from human PSCs for developing atopic dermatitis.
[Korea Biomedical Review] |
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| The governing Board of the California Institute for Regenerative Medicine has approved a trio of awards, totaling approximately $4 million, to University of California San Diego School of Medicine researchers to advance studies of new stem cell-based treatments for multiple types of cancer and amyotrophic lateral sclerosis.
[UC San Diego Health] |
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| | October 19, 2021
London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Helmholtz Zentrum Münche – Neuherberg, Germany |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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