 | | Vol. 2.34 – 9 September, 2021 |
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| Mouse mammary tumor organoids were established by encapsulating tumor pieces in non-adhesive alginate and were treated with doxorubicin and latrunculin A to evaluate their application as a drug screening platform.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators utilized forebrain organoids generated from iPSCs of patients with a syndromic form of Autism Spectrum Disorder with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development.
[Nature Communications] |
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| Whole-exome and total RNA sequencing was performed on 137 samples from 121 microsatellite stable colorectal cancers, including multiregional samples of primary and metastatic tumors from 4 patients.
[Genome Medicine] |
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| Researchers presented a multiplexed mass cytometry protocol for single-cell analysis of post-translational modification signaling and cell states in organoids and organoids co-cultured with fibroblasts and leukocytes.
[Nature Protocols] |
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| Scientists reported the first bladder cancer organoid-based small molecule screening for epigenetic drugs. They found that SRT1720, a Sirtuin 1 (SIRT1) activator, significantly inhibited the growth of both mouse and human bladder cancer organoids
[Oncogene] |
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| Researchers established and characterized endometrial assembloids, consisting of gland-like organoids and primary stromal cells. Single-cell transcriptomics revealed that decidualized assembloids closely resembled midluteal endometrium, harbouring differentiated and senescent subpopulations in both glands and stroma.
[eLife] |
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| Scientists presented MOrgAna, a Python-based software that implements machine learning to segment images, quantify and visualize morphological and fluorescence information of organoids across hundreds of images, each with one object, within minutes.
[Development] |
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| The authors investigated the ability of renal organoids to undergo nephrogenesis upon Wnt/ β-catenin pathway – mediated tubule induction with a GSK-3 inhibitor or by initiation through the ureteric bud.
[Developmental Dynamics] |
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| Investigators explored the establishment of lung bud organoids by systematically adjusting the initial confluence levels and homogeneity of cell distribution.
[Clinical Hemorheology and Microcirculation] |
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| The authors outline the the Human Developmental Cell Atlas initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation.
[Nature] |
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| The authors discuss how deficits in neurodevelopmental processes may lead to abnormal brain connectivity and how iPSC-based models can be used to identify abnormal connections and to gain insights into underlying cellular and molecular mechanisms to develop novel therapeutics.
[Molecular Psychiatry] |
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| Investigators developed precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.
[Stem Cell Research & Therapy] |
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| Gain Therapeutics, Inc. announced topline data from the company’s study, conducted at the University of Maryland School of Medicine. The study, evaluating two lead Structurally Targeted Allosteric Regulators (STARs) compounds for the treatment of Gaucher and GBA1 Parkinson’s Disease, demonstrated positive effects on all tested phenotypes.
[Gain Therapeutics, Inc.] |
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| October 19 – 20, 2021
Virtual |
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| | Duke-NUS Medical School – Singapore, Singapore |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Helmholtz Zentrum Münche – Neuherberg, Germany |
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| | Cold Spring Harbor Laboratory – Long Island, New York, United States |
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