 | | Vol. 2.35 – 16 September, 2021 |
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| Experimental in vitro models that capture pathophysiological characteristics of human tumors are essential for basic and translational cancer biology. Researchers described a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.
[Nature Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used viscoelastic alginate hydrogels with independently tunable stress relaxation, stiffness, and arginine–glycine–aspartate ligand density to study human iPSC morphogenesis in 3D culture.
[Advanced Materials] |
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| In mouse models of liver injury, ductular reaction cells express genes involved in angiogenesis. In vitro, human liver-derived organoids produced SLIT2 and induced tube formation of endothelial cells.
[Hepatology] |
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| Scientists profiled the chromatin landscape and androgen receptor-directed transcriptional program in normal prostate cells and showed the impact of SPOP mutations, an early event in prostate tumorigenesis.
[Cell Reports] |
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| The authors described a new video microscopy technique that harnessed a metric of motion-contrast imaging and image correlation for ciliary beat frequency analysis.
[IEEE Transactions On Medical Imaging] |
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| Investigators established a robust, high-throughput cochlear organoid platform that facilitates 3D expansion of cochlear progenitor cells and differentiation of hair cells in a temporally regulated manner.
[Stem Cell Reports] |
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| Scientists developed a low-viscosity matrix suspension culture method that enabled efficient establishment and propagation of organoids and tumoroids from the human large intestine.
[Communications Biology] |
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| Researchers used a data-driven approach, combining results from the screening of a large transcriptomic database and molecular docking analyses, with in vitro tests using a lung organoid model of SARS-CoV-2 entry, to identify drugs with putative multimodal properties against COVID-19.
[Molecular Medicine] |
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| Pharmacokinetic assessment of hydroxychloroquine (HCQ) in non-tumor bearing mice following intraperitoneal dosing established 60 mg/kg as the human equivalent dose of HCQ in mice.
[Journal of Pharmacology and Experimental Therapeutics] |
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| Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.
[American Journal of Physiology-Cell Physiology] |
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| The authors explore the opportunities and challenges resulting from the convergence of organoid high-throughput screening and AI-driven data analytics and outline potential future avenues toward the discovery of novel mechanisms and drugs in Parkinson’s disease research.
[Movement Disorders] |
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| Investigators review the evolution and scope of organoid technology, highlight recent encouraging results using patient-derived organoids as potential patient “avatars” to predict drug response and outcomes, and discuss critical parameters for widespread clinical adoption.
[Med] |
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| The California Institute for Regenerative Medicine has awarded $31 million to three Stanford researchers to launch trials of treatments for common diseases. Four other Stanford researchers also received a total of $4.55 million.
[Stanford Medicine] |
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| November 15 – 19, 2021
Virtual |
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| | MaxWell Biosystems – Zurich, Switzerland |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | Duke-NUS Medical School – Singapore, Singapore |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
