Organoid News Volume 2.36 | Sep 23 2021

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    2021-09-23 | ON 2.36


    Organoid News by STEMCELL Technologies
    Vol. 2.36 – 23 September, 2021
    TOP STORY

    Human Microglia States Are Conserved across Experimental Models and Regulate Neural Stem Cell Responses in Chimeric Organoids

    Xenotransplantation of human microglia into cerebral organoids allowed us to characterize key transcriptional programs of developing microglia in vitro and revealed that microglia induced transcriptional changes in neural stem cells and decrease interferon signaling response genes.
    [Cell Stem Cell]

    AbstractGraphical Abstract
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    KIR3DS1 Directs NK Cell-Mediated Protection against Human Adenovirus Infections

    To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.
    [Science Immunology]

    AbstractPress Release

    A CRISPR/Cas9 Genetically Engineered Organoid Biobank Reveals Essential Host Factors for Coronaviruses

    To discern which host factors were reliable anti-coronavirus therapeutic targets, investigators generated mutant clonal IOs for 19 host genes previously implicated in coronavirus biology.
    [Nature Communications]

    Full ArticlePress Release

    FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

    The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance
    [Molecular Therapy]

    Abstract

    Human Stem Cell-Based Retina on Chip as New Translational Model for Validation of AAV Retinal Gene Therapy Vectors

    By employing their recently developed retina on chip that merged organoid and organ-on-chip technology, scientists analyzed the efficacy, kinetics, and cell tropism of seven first- and second-generation adeno-associated virus (AAV) vectors.
    [Stem Cell Reports]

    Full Article

    Programmatic Introduction of Parenchymal Cell Types into Blood Vessel Organoids

    The authors presented a bottom-up engineering approach to building vascularized human tissue by combining genetic reprogramming with chemically directed organoid differentiation.
    [Stem Cell Reports]

    Full Article

    Investigating Receptor-Mediated Antibody Transcytosis Using Blood–Brain Barrier Organoid Arrays

    Investigators applied a novel bioengineering approach to generate human blood-brain barrier organoids by the self-assembly of astrocytes, pericytes and brain endothelial cells with unprecedented throughput and reproducibility using micro patterned hydrogels.
    [Fluids and Barriers of the CNS]

    Full Article

    Limosilactobacillus reuteri ATCC 6475 Metabolites Upregulate the Serotonin Transporter in the Intestinal Epithelium

    The authors reported that the intestinal commensal microbe Limosilactobacillus reuteri ATCC PTA 6475 secretes 83.4 mM ethanol. Consistent with the activity of L. reuteri alcohol dehydrogenases, they found that L. reuteri tolerated various levels of ethanol.
    [Beneficial Microbes]

    Abstract

    Novel Insights into the Molecular Mechanisms Underlying Risk of Colorectal Cancer from Smoking and Red/Processed Meat Carcinogens by Modeling Exposure in Normal Colon Organoids

    Scientists performed a 24 hour treatment of a representative carcinogens cocktail in 37 independent organoid lines derived from normal colon biopsies.
    [Oncotarget]

    Abstract

    Identification of Predictive Markers for the Generation of Well-Differentiated Human Induced Pluripotent Stem Cell-Derived Kidney Organoids

    To associate the quality of kidney organoid differentiation with predictive markers, a ranking system was developed based on the ratio of nephron structure determined by histological examination.
    [Stem Cells and Development]

    Abstract
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    REVIEWS

    What Can Biofabrication Do for Space and What Can Space Do for Biofabrication?

    Microgravity enables biofabrication of tissue and organ constructs of more complex geometries, thus facilitating novel scaffold-, label-, and nozzle-free technologies based on multi-levitation principles.
    [Trends in Biotechnology]

    Full Article

    Studying the Role of Chromosomal Instability (CIN) in GI Cancers Using Patient-Derived Organoids

    The authors review the importance of patient-derived tumor organoids as a model to study chromosomal instability in cancers of the gastrointestinal tract.
    [Journal of Molecular Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    UCLA Broad Stem Cell Research Center Receives $5 Million CIRM Grant for Research Training Program

    The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has been awarded $5 million by the California Institute for Regenerative Medicine, the state’s stem cell agency, to train young scientists and physicians to become leaders in the stem cell and regenerative medicine field.
    [University of California]

    Press Release

    ALSAM Research Foundation Awarded Grant to Dr. Paris Jafari

    Dr. Paris Jafari, Research Assistant Professor in the Department of Pharmaceutics has recently been awarded a grant from the ALSAM Research Foundation to finance her research on 3D bioprinting of Organoid Cancer Models.
    [University of Utah]

    Abstract
    FEATURED EVENT

    6th World Congress of the Tissue Engineering and Regenerative Medicine International Society

    November 15 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Brain Stem Cell Researcher

    University of Helsinki – Helsinki, Finland

    PhD Project – Cortical Expansion and Neurodevelopment Disorders

    Aberdeen University – Aberdeen, Scotland, United Kingdom

    Research Assistant – Regenerative Medicine for the Biliary System

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Neuronal Cell Biologist – Functional CRISPRi Screening of Parkinson’s Gene in Human iPSC Neurons

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Position – Stem Cells and Disease Modeling

    King Abdullah University of Science and Technology – Thuwal, Saudi Arabia

    > See All Jobs

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