 | | Vol. 2.37 – 7 October, 2021 |
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| By forced expression of the ectodysplasin-A in human epidermal keratinocytes sweat gland (SwG) culture medium, human epidermal keratinocytes were efficiently converted into SwG cells.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.
[Nature Communications] |
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| To understand whether transcriptional activity of RING-finger protein 6 (RNF6) underlied its oncogenic effect, the authors performed integrated chromatin immunoprecipitation-sequencing and RNA-sequencing analysis to identify splicing factor 3b subunit 2 (SF3B2) as a potential downstream target of RNF6.
[Oncogene] |
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| Investigators reported serum-free conditions that allowed for growth and differentiation of mouse distal lung epithelial progenitors.
[eLife] |
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| Using a human fetal lung organoid system as an example the authors systematically developed and optimized a complete genetic toolbox for use in tissue-derived organoids.
[eLife] |
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| Scientists reported that metformin treatment increased the sensitivity of hepatocarcinoma cells to methotrexate by suppressing the expression of the one-carbon metabolism enzyme dihydrofolate reductase.
[Cell Death & Disease] |
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| Researchers examined the role of DKK3 by overexpression and knockdown and discovered that DKK3 suppressed Wnt signaling in APC-null murine colonic organoids and human colon cancer cells despite the presence of downstream activating mutations in the Wnt pathway.
[Molecular Cancer Research] |
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| Scientists successfully established five gallbladder carcinoma and one extrahepatic cholangiocarcinoma patient-derived organoids (PDOs). Histological staining was used to compare structural features between the original tissues and cancer PDOs.
[Cancer Cell International] |
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| Using orthogonal flow cytometry analysis, scientists demonstrated that primary patient-derived cancer organoid maintain distinct subsets of epithelial cells throughout culture and that these cells conserve expression of androgen receptor-related elements.
[Medical Oncology] |
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| Investigators explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity.
[Physiological Genomics] |
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| Genetically modified organoids have been developed by sequential knockout and knockin of driver mutations by genome editing followed by niche-based selection.
[Hepatology International] |
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| Scientists discuss the patient-derived organoids as a native tumor microenvironment mimicking model in personalized cancer therapy.
[Experimental Cell Research] |
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| Magee-Womens Research Institute will award the $1 million Magee Prize to an international team of scientists during the Magee-Womens Summit Nov. 16 to 18. The prize will help fund new research initiatives and transdisciplinary collaborations to promote knowledge and enhance the health and wellness of women and infants worldwide.
[University of Pittsburgh Schools of the Health Sciences] |
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| Prostate cancer researcher Dr. John Lee garnered a National Institutes of Health New Innovator Award to fund his breakthrough approach that promises to help make scientific tumor models better capture the complex biology of tumors that arise naturally.
[Fred Hutchinson Cancer Research Center] |
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| November 1 – 3, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | Insituto Italiano Di Tecnologia – Genoa, Italy |
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| | Imperial College London – London, England, United Kingdom |
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| | University of Helsinki – Helsinki, Finland |
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