 | | Vol. 2.38 – 14 October, 2021 |
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| The authors observed increased plasma cell proportions in diffuse-type tumors associated with epithelial-resident KLF2, and stage-wise accrual of cancer-associated fibroblast sub-populations marked by high INHBA and FAP co-expression.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified a KRAB-ZFP transcription factor, ZNF558, that was expressed in human but not chimpanzee forebrain neural progenitor cells.
[Cell Stem Cell] |
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| A facile 3D-bioassembly platform was introduced to primarily study fusion of cartilage–cartilage interfaces using spheroids formed from human mesenchymal stromal cells and articular chondrocytes.
[Advanced Science] |
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| The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.
[ACS Nano] |
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| Four patient-derived xenografts, two patient-derived organoi and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of 6-thio-2′-deoxyguanosine.
[Clinical Cancer Research] |
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| Investigators evaluated the difference between controls’ and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients’ derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.
[Movement Disorders] |
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| Researchers investigated the function of argininosuccinate synthetase (ASS1) in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.
[Cell Death & Disease] |
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| Experiments in piglet jejunum organoids revealed that the mix of amino acids and polyphenols upregulated the gene expression of epithelial differentiation markers while it reduced the gene expression of proliferation and innate immunity markers.
[Amino Acids] |
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| Scientists investigated the effects of early geometric confinements on transcriptomic changes during human cerebral organoids differentiation.
[BMC Biotechnology] |
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| Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions.
[Annual Review of Medicine] |
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| The authors review the three methods currently used to establish glioma organoids, and introduced how they play a role in the diagnosis and treatment of glioma.
[Cell Communication and Signaling] |
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| Organoid-derived intestinal co-culture models have established themselves as convenient tools to re-enact pathophysiological events, explore interactions between selected cell populations and assess their roles with a central focus on intestinal barrier recovery and stabilization.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Smart Immune SAS, a T cell medicine company utilizing its proprietary ex vivo biomimetic “thymus in a dish” technology to develop allogeneic T-cell progenitors Smart101 for rapid immune reconstitution, announced that the institutional review board (IRB) of the Memorial Sloan Kettering Cancer Center has approved the commencement of the company’s Phase I/II clinical trial.
[Smart Immune SAS] |
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| November 22 – 24, 2021
Virtual |
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| | Hyper Recruitment Solutions – Oxfordshire, England, United Kingdom |
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| | Hyper Recruitment Solutions – Oxfordshire, England, United Kingdom |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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