 | | Vol. 2.39 – 21 October, 2021 |
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| Researchers reported the development of a cerebral organoid slice model derived from human induced pluripotent stem cells that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 amyotrophic lateral sclerosis overlapping with frontotemporal dementia.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used cerebral organoids to identify key roles of neurotransmitter signaling pathways in guiding the migratory behavior of human cortical interneurons.
[EMBO Journal] |
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| In multiple hepatocellular carcinoma patient-derived organoids and human tumor xenograft models, the drug combination, but neither single drug alone, markedly reduced tumor-initiating cancer cell frequency.
[Cancer Research] |
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| It is urgent to develop disease models to dissect mechanisms regulating SARS-CoV-2 infection. Researchers derived airway organoids from human pluripotent stem cells.
[Cell Reports] |
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| Human duodenal organoids were CRISPR-Cas9 modified to express the fluorescent protein Venus or the Ca2+ sensor GCaMP7s under control of the endogenous motilin promoter.
[Molecular Metabolism] |
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| Investigators generated leber congenital amaurosis caused by mutations in CRX (LCA7) retinal organoids harboring a dominant disease-causing mutation in CRX. The LCA7 retinal organoids developed signs of immature and dysfunctional photoreceptor cells, providing a reliable in vitro model to recapitulate LCA7.
[Stem Cell Reports] |
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| Researchers modeled Fabry disease using human iPSC-derived kidney organoids and the CRISPR–Cas9 genome-editing system.
[Experimental & Molecular Medicine] |
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| Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.
[Translational Psychiatry] |
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| The authors assessed induction of cystic fibrosis transmembrane conductance regulator (CFTR) function in premature termination codons-containing intestinal organoids using compounds targeting readthrough, nonsense mRNA mediated decay and CFTR protein modulation.
[Journal of Cystic Fibrosis] |
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| Scientists utilized no known disease/healthy cerebral organoids (COs) as normal function controls. At 3–4 and 6–10 months post-differentiation, COs with mutations showed no evidence of disease-related pathology.
[Molecular Brain] |
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| Organoids hold great potential for high-content screening because they recapitulate many aspects of parent tissues and can be derived from patient material.
[Experimental & Molecular Medicine] |
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| The authors focus on adult gastrointestinal organoids and summarize the state-of-the-art protocols for successful transgenesis.
[Experimental & Molecular Medicine] |
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| Investigators describe different gastrointestinal organoid methodologies and their applications for basic and translational cancer research.
[Experimental and Molecular Medicine] |
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| The International Space Station (ISS) National Laboratory has unveiled a research announcement seeking proposals to demonstrate biomanufacturing activities in microgravity.
[The International Space Station] |
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| A $15.4 million investment in the Rebuild Illinois-funded Wet Lab Capital program will support eight new wet lab spaces throughout Illinois, helping to make way for advancements in research and medicine, grow startups, and make Illinois more competitive in life sciences.
[Business Facilities] |
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| November 3 – 5, 2021
Lleida, Spain |
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| | Herophilus – San Francisco, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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