 | | Vol. 2.40 – 28 October, 2021 |
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| An in vitro model of fetal human brain development, human iPSC–derived cerebral organoids, were used to test whether cerebral organoids were suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.
[American Journal of Psychiatry] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that both PSC-derived human intestinal organoids engrafted into mice and patient-derived human intestinal enteroids possessed circadian rhythms and demonstrated circadian phase-dependent necrotic cell death responses to Clostridium difficile toxin B.
[EMBO Journal] |
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| The authors presented a method to model the peristalsis for human colon tumor organoids on a microfluidic chip.
[Biofabrication] |
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| Researchers optimized differentiation of airway organoids (AOs) towards ciliated cells. After differentiation of the AOs towards ciliated cells, these could be studied for weeks.
[EMBO Reports] |
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| The authors presented a method that combined cryo-correlative light microscopy and electron tomography with human cerebral organoid technology to visualize growing axon tracts.
[eLife] |
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| Investigators examined the vertical-mixing effect on brain organoid structures using bioreactors and established inverted brain organoids.
[Communications Biology] |
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| The authors reported that human iPSC-derived retinal organoids released exosomes and microvesicles with small noncoding RNA cargo.
[Scientific Reports] |
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| Scientists created organoid microarrays and visualized bulk and spatial differences in cell proliferation using immunohistochemistry staining, and cell cycle analysis by flow cytometry paired with 3D regional labeling.
[Translational Oncology] |
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| Researchers generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.
[American Journal of Physiology-Cell Physiology] |
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| Investigators discuss dynamic and non-overlapping spatiotemporal protein-level programs and their potentially essential role for unraveling critical secreted paracrine signals or neurodevelopmental proteins requiring post-translational modification for biological activity.
[Molecular Psychiatry] |
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| The authors provide a retrospective account of organoid methodologies and outline new opportunities for optimizing these methods to further explore emerging concepts in lung biology.
[Trends in Molecular Medicine] |
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| Signet Therapeutics and XtalPi Inc. announced the expansion of their AI drug discovery collaboration to include a new first-in-class program against a novel cancer target identified by Signet, and continue to combine XtalPi’s AI drug discovery platform with Signet’s unique novel organoid disease models.
[XtalPi] |
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| MASORI Therapeutics and Vyant Bio, Inc. announced they entered into an agreement to pursue co-development and out-licensing partnerships with pharmaceutical and biotechnology companies.
[MASORI Therapeutics (GlobeNewswire, Inc.)] |
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| November 15 – 17, 2021
Virtual |
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| | Radboud University Medical Center – Nijmegen, The Netherlands |
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| | Herophilus – San Francisco, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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