Organoid News Volume 2.41 | Nov 4 2021

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    2021-11-04 | ORGN 2.41


    Organoid News by STEMCELL Technologies
    Vol. 2.41 – 4 November, 2021
    TOP STORY

    An Organoid-Based Screen for Epigenetic Inhibitors That Stimulate Antigen Presentation and Potentiate T Cell-Mediated Cytotoxicity

    Researchers reported a high-throughput screen based on the functional interaction of mouse- or patient-derived breast tumor organoids and tumor-specific cytotoxic T cells for the identification of epigenetic inhibitors that promoted antigen presentation and potentiated T cell-mediated cytotoxicity.
    [Nature Biomedical Engineering]

    Abstract

    Culture Mouse Intestinal Organoids With On-Demand Training. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    Generation of Offspring-Producing 3D Ovarian Organoids Derived from Female Germline Stem Cells and Their Application in Toxicological Detection

    Scientists showed that an ovarian model generated normal offspring and detected drug toxicity. The ovarian organoids produced oocytes and exhibited endocrine functions.
    [Biomaterials]

    Full Article

    High-Throughput On-Chip Human Mesenchymal Stromal Cell Potency Prediction

    Investigators presented a high-throughput, scalable, low-cost, on-chip microfluidic potency assay with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches.
    [Advanced Healthcare Materials]

    Abstract

    Bacterial Cancer Therapy of Autochthonous Colorectal Cancer Impacts Tumor Growth and Metabolic Landscape

    Researchers aimed to better understand the tumor epithelium-targeted mechanisms of bacterial cancer therapy by using autochthonous mouse models of intestinal cancer and tumor organoid cultures to assess the effectiveness and consequences of oral treatment with aromatase A-deficient Salmonella enterica serovar Typhimurium.
    [JCI Insight]

    AbstractGraphical Abstract

    Aurora Kinase a Regulates Liver Regeneration through Macrophages Polarization and Wnt/β-Catenin Signaling

    The effect and mechanism of aurora kinase A (AURKA) on liver regeneration were studied using a 70% hepatectomy model. Human liver organoids were used as an in vitro model to investigate the effect of AURKA on hepatocyte proliferation.
    [Liver International]

    Abstract

    Cep55 Regulation of PI3K/Akt Signaling Is Required for Neocortical Development and Ciliogenesis

    The elevated apoptosis of neural stem/progenitors was recapitulated using Cep55-deficient human cerebral organoids and investigators could rescue the phenotype by inhibiting active Gsk3β.
    [PLoS Genetics]

    Full ArticlePress Release

    Vascularization of iNSC Spheroid in a 3D Spheroid-on-a-Chip Platform Enhances Neural Maturation

    The authors created a 3D model of vascularized spheroid cells using an injection-molded microfluidic chip. Gene expression analysis and immunostaining revealed that the vascular network greatly enhanced spheroid differentiation and reduced apoptosis.
    [Biotechnology and Bioengineering]

    Abstract

    Patient-Derived Organoids as a Platform for Modeling a Patient’s Response to Chemoradiotherapy in Esophageal Cancer

    Investigators described a pilot prospective observational study with the goal of determining whether esophageal cancer patient-derived organoids created from treatment-naive patients could model or predict clinical outcomes.
    [Scientific Reports]

    Full Article

    Intraperitoneal Administration of Human “Neo-Islets”, 3-D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells, Normalizes Blood Glucose Levels in Streptozotocin-Diabetic NOD/SCID Mice: Significance for Clinical Trials

    A new “endocrine pancreas” delivered islet hormones physiologically into the hepatic portal vein. Treatment of insulin-dependent dogs with allogeneic canine neo-islets consistently improved glycemic control without the need for antirejection drugs.
    [PLoS One]

    Full Article

    Five tips for returning to the lab after time off
    REVIEWS

    Tumor Organoids: Synergistic Applications, Current Challenges, and Future Prospects in Cancer Therapy

    Advances in 3D organoid culture technology have led to the development of novel physiological systems that model the tissues of origin more precisely than traditional culture methods.
    [Cancer Communications]

    Full Article

    INDUSTRY AND POLICY NEWS

    XtalPi and Signet Expand AI Drug Discovery Collaboration to Novel Cancer Target

    Signet Therapeutics and XtalPi Inc. announced the expansion of their AI drug discovery collaboration to include a new first-in-class program against a novel cancer target identified by Signet, combining XtalPi’s AI drug discovery platform with Signet’s unique novel organoid disease models.
    [XtalPi, Inc. (PR Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Cell Bio Virtual 2021

    December 1 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Mammalian Synthetic Biology and Organoid Engineering

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Organoid Development

    Roche – Basel, Switzerland

    Faculty Position – Neuroscience

    The Ecole Polytechnique Fédérale de Lausanne – Lausanne, Switzerland

    Principal Investigator – Organoid Biology

    VIB Center for Inflammation Research – Ghent, Belgium

    Research Technician – Retina-on-Chip

    Radboud University Medical Center – Nijmegen, The Netherlands

    > See All Jobs

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