Organoid News Volume 2.42 | Nov 18 2021

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    2021-11-18 | ON 2.42


    Organoid News by STEMCELL Technologies
    Vol. 2.42 – 18 November, 2021
    TOP STORY

    Schizophrenia Is Defined by Cell-Specific Neuropathology and Multiple Neurodevelopmental Mechanisms in Patient-Derived Cerebral Organoids

    Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.
    [Molecular Psychiatry]

    Full Article

    A Labroots 2021 Webinar: iPSCs As Models, Part 1: What Are Induced Pluripotent Stem Cells and How Do You Use Them?, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Infection and Replication in Human Gastric Organoids

    Researchers generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection.
    [Nature Communications]

    Full Article

    HER3 is an Actionable Target in Advanced Prostate Cancer

    Investigators showed that membranous HER3 protein was commonly highly expressed in lethal prostate cancer, associating with reduced time to castration resistance and survival.
    [Cancer Research]

    Abstract

    The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma

    High-throughput RNA-seq was used to identify the differentially expressed circRNAs upon IL-6 stimulation in intrahepatic cholangiocarcinoma cells.
    [Hepatology]

    Abstract

    Cross-Validation of SARS-CoV-2 Responses in Kidney Organoids and Clinical Populations

    Scientists combined SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics.
    [JCI Insight]

    AbstractFull ArticleGraphical Abstract

    A New Murine Esophageal Organoid Culture Method and Organoid-Based Model of Esophageal Squamous Cell Neoplasia

    Researchers developed an esophageal minimum essential organoid culture medium for culturing murine esophageal organoid and establishing an early esophageal squamous cell carcinoma model.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Murine Cerebral Organoids Develop Network of Functional Neurons and Hippocampal Brain Region Identity

    Scientists developed a highly standardized, reproducible and fast murine brain organoid model starting from embryonic neural stem cells.
    [iScience]

    AbstractGraphical Abstract

    Developmental Defects and Impaired Network Excitability in a Cerebral Organoid Model of KCNJ11 p.V59M-Related Neonatal Diabetes

    Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.
    [Scientific Reports]

    Full Article

    Proteasome Inhibitors Restore the STAT1 Pathway and Enhance the Expression of MHC Class I on Human Colon Cancer Cells

    The authors applied three colon cancer cell lines, including microsatellite stable cell lines, which are SW480 and SW620, and microsatellite instability-high cell line, which is DLD-1.
    [Journal of Biomedical Science]

    Full Article

    Genome Analysis Identifies Differences in the Transcriptional Targets of Duodenal versus Pancreatic Neuroendocrine Tumors

    Researchers identified the possible derivation of gastroenteropancreatic neuroendocrine tumors using genome-wide analyses to distinguish small intestinal neuroendocrine tumours, specifically duodenal gastrinomas from pancreatic neuroendocrine tumors.
    [BMJ Open Gastroenterology]

    Abstract
    Watch the Webinar On-Demand: “Re-Creating Disease with Kidney Organoids and CRISPR-Cas9”
    REVIEWS

    Human Brain Organogenesis: Toward a Cellular Understanding of Development and Disease

    Scientists review recent progress on uncovering the cellular and molecular principles of human brain organogenesis in vivo as well as using organoids and assembloids in vitro to model features of human evolution and disease.
    [Cell]

    Full Article

    Generation of Skin Organoids: Potential Opportunities and Challenges

    Investigators summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and discuss the opportunities and challenges associated with multifunctional skin organoids.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Current Status of Breast Organoid Models

    The applications, components, and protocols for the development of breast organoids are discussed. Scientists summarize studies that describe the utility of breast organoids, including in the study of normal mammary gland development and tumorigenesis.
    [Frontiers in Bioengineering and Biotechnology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Kronos Bio and Tempus Announce Multi-Year Collaboration to Provide Kronos Bio with Access to Tempus’ Platform

    Kronos Bio, Inc. announced a multi-year collaboration that will provide Kronos Bio with access to Tempus’ real-world genomic and transcriptomic data and data analytics tools.
    [Kronos Bio, Inc.]

    Press Release

    Pitt Researchers Part of International Team Awarded $1 Million Magee Prize

    At the Magee-Womens Summit, Magee-Womens Research Institute (MWRI) awarded the $1 million Magee Prize to an international team led by Dr. Pamela Moalli director of urogynecology and pelvic reconstruction surgery at UPMC Magee-Womens Hospital and MWRI.
    [Magee-Womens Research Institute and Foundation]

    Press Release
    FEATURED EVENT

    Stem Cell Society Singapore Symposium 2021

    December 8 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cell Biology And Genomics Of Liver Injury

    Emory University – Atlanta, Georgia, United States

    Postdoctoral Position – Infection/Organoid Biology

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Scholar – Regenerative Medicine

    University of Southern California School of Dentistry – Los Angeles, California, United States

    Postdoctoral Research Fellow – Mammalian Synthetic Biology and Organoid Engineering

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Organoid Development

    Roche – Basel, Switzerland

    > See All Jobs

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