 | | Vol. 2.43 – 25 November, 2021 |
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| Investigators described the discovery of an agonist of the nuclear receptor NR2F1 that specifically activated dormancy programs in malignant cells.
[Journal of Experimental Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Prospectively generate patient derived organoids were established from a heterogeneous population of patients with pancreatic ductal adenocarcinoma (PDAC) including both basal and classical PDAC subtypes.
[Clinical Cancer Research] |
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| Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.
[Journal For Immunotherapy of Cancer] |
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| Scientists established a novel in vitro pulmonary fibrosis model using alveolar organoids consisting of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts.
[Stem Cell Reports] |
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| Researchers demonstrated the generation of more advanced in vitro multiocular organoids from human iPSCs. In the 2D culture, self-formed multizone ocular progenitor cells spanned the neuroectoderm, surface ectoderm, neural crest, and retinal pigment epithelium, mimicking early stages of eye development.
[Stem Cell Research & Therapy] |
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| The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.
[Cellular Oncology] |
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| The authors performed whole-genome sequencing on clonally expanded single liver stem cells cultured as intrahepatic cholangiocyte organoids from patients with alcoholic cirrhosis, non-alcoholic steatohepatitis, and primary sclerosing cholangitis.
[Communications Biology] |
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| Scientists investigated the effect of SSP2518 on guanylyl cyclase C (GCC)-mediated intracellular cyclic guanosine monophosphate levels and on GCC-mediated chloride secretion in intestinal organoids from three patients with distinct activating GCC mutations and from controls.
[Clinical and Translational Gastroenterology] |
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Researchers reported the first comprehensive assessment of cryopreservation of endometrial organoids in the domestic mare.
[Cryobiology] |
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| Scientists highlight emerging technologies and infection models that recently promoted opportunities in cellular microbiology.
[Nature Communications] |
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| Investigators discuss how organoid shape is controlled by mechanical cues within the organoid and their interplay with the material properties of the environment.
[Current Opinion in Genetics & Development] |
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| Eloxx Pharmaceuticals, Inc. announced positive topline results from the monotherapy arms of its Phase II clinical trial of ELX-02 in Class 1 cystic fibrosis patients with at least one G542X nonsense allele mutation.
[Eloxx Pharmaceuticals, Inc.] |
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| Dr. Lin Ma is the recipient of STEM CELLS’s Young Investigator Award for 2021. Her work on engineering hypoimmunogenic human PSCs exemplifies the potential of the field and promise of this young next generation of researchers.
[ALPHAMED PRESS (EurekAlert!)] |
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| December 8 – 9, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | Emory University – Atlanta, Georgia, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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