 | | Vol. 2.45 – 9 December, 2021 |
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| Scientists of their endometrial organoids revealed the pathways and cell states regulating differentiation of the secretory and ciliated lineages both in vivo and in vitro.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors described a human multilineage iPSC-derived organoid that recapitulated cooperative cardiac and gut development and maturation, with extensive cellular and structural complexity in both tissues.
[Cell Stem Cell] |
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| Researchers developed an organoid assembly approach starting with cells from the three primary germ layers— enteric neuroglial, mesenchymal, and epithelial precursors— that were derived separately from human PSCs.
[Cell Stem Cell] |
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| Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.
[Biomaterials] |
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| Using Zfp683 reporter mice, scientists showed that correlation of Hobit expression with type 1 innate lymphoid cells was tissue- and context-dependent.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Cell-based assays, primary organoid cultures, and pregnane X receptor (PXR) conditional knockout and PXR-humanized mouse models were used to investigate the impact of DCHP exposure on PXR activation and lipid homeostasis in vitro and in vivo.
[Environmental Health Perspectives] |
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| AL-GDa62 preferentially induced apoptosis in CDH1–/– cells, and Cdh1–/– mammary and gastric organoids were significantly more sensitive to AL-GDa62 at low micromolar concentrations.
[Journal of Medicinal Chemistry] |
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| Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.
[PLoS Genetics] |
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| Investigators generated UM-002, a novel brain penetrant bromodomain and extraterminal domain (BET) inhibitor that reduced glioblastoma cell proliferation in vitro and in a human cerebral brain organoid model.
[Scientific Reports] |
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| The authors utilized a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with in vitro 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion.
[Molecular Biology of the Cell] |
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| Investigators attempted to better understand organoids by focusing on the choice of the best housekeeping gene to perform accurate molecular analysis on such a heterogeneous system.
[PLoS One] |
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| Co-cultured using a magnetic spheroid formation approach, conditionally immortalized human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.
[Communications Biology] |
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| Transformation of conventional 2D platforms into unusual 3D configurations provides exciting opportunities for sensors, electronics, optical devices, and biological systems.
[Small] |
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| Investigators describe the decellularization and sterilization methods that are commonly used in recent research, and the effects of these methods upon biologic scaffold material.
[Artificial Organs] |
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| Abu Dhabi Stem Cells Centre has signed a research agreement with National Institute of Allergy and Infectious Diseases of the US to develop treatments for chronic diseases.
[The National] |
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| NextVivo emerged from stealth with $7.9M in financing led by Khosla Ventures, with participation from Alexandria Venture Investments with plans to develop the first organoid platform able to generate and test therapies in immune-competent human-derived models.
[NextVivo (BusinessWire, Inc.)] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| | iCamuno Biotherapeutics – Melbourne, Australia |
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| | Washington University – St. Louis, Missouri, United States |
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| | KU Leuven – Leuven, Belgium |
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| | Accession Therapeutics – Oxford, England, United Kingdom |
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