 | | Vol. 2.46 – 16 December, 2021 |
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| Researchers presented a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting colorectal cancer counterparts.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists exploited an innovative cellular approach allowing highly efficient in vitro expansion of airway epithelial stem cells through conditional reprogramming from nasal brushing of cystic fibrosis patients.
[European Respiratory Journal] |
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| Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.
[Nature Communications] |
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| Scientists translated a newly developed pooled RNA-seq methodology onto a superhydrophobic microwell array chip to realize an assay of genome-wide RNA output unified with phenotypic data.
[Nucleic Acids Research] |
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| The authors illustrated how pregnancy-induced changes modulate the communication between mammary epithelial cells and the immune microenvironment and established a causal link between pregnancy, the immune microenvironment, and mammary oncogenesis.
[Cell Reports] |
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| By applying outer plexiform layer (OPL) staging criteria to human retinal organoids derived from human embryonic and iPSC, scientists observed comparable maturation from OPL-Stage 0 at day 100 in culture up to OPL-Stage 3 by day 160.
[Development] |
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| Investigators found that halofuginone inhibited the proliferation, induced G0/G1 phase arrest, and promoted apoptosis in lung cancer cells in a dose-dependent manner.
[Frontiers in Cell and Developmental Biology] |
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| Researchers comprehensively compared three popular Matrigel dissolving methods and investigated the effect of undissolved Matrigel proteins on proteomic profiles of organoids.
[Molecular & Cellular Proteomics] |
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| Investigators generated a prospective cohort of 27 consecutive biopsied derived pancreatic organoids and included them in the signature identification strategy.
[Translational Oncology] |
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| Work in model systems has provided insights into the biology of lung cancer subtypes and their origins, contributed to our understanding of the mechanisms that underlie tumor progression, and revealed new therapeutic vulnerabilities.
[Cold Spring Harbor Perspectives in Medicine] |
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| The advent of brain organoid technology has provided a new means to study the cause and progression of developmental brain diseases in vitro.
[Journal of Molecular Biology] |
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| The authors discuss promising Matrigel-free methods for the generation and maintenance of organoids that use decellularized ECM, synthetic hydrogels, or gel-forming recombinant proteins.
[Communications Biology] |
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| Cerevel Therapeutics announced a phased multi-year, joint research collaboration in neuropsychiatry. The collaboration integrates the deep expertise in neuroscience drug discovery at Cerevel Therapeutics with state-of-the-art disease models and the AI-enabled deep phenotyping from Herophilus.
[Cerevel Therapeutics] |
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| Launched in 2016, the adventure is coming to an end after five years of work carried out within the CHOlesterol Personalized INnovation, and with a strong collaboration between HCS Pharma and l’Institut du thorax.
[HCS Pharma] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Ecole polytechnique fédérale de Lausanne – Lausanne, Canton of Vaud |
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| | Washington University – St. Louis, Missouri, United States |
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| | iCamuno Biotherapeutics – Melbourne, Australia |
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| | Washington University – St. Louis, Missouri, United States |
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