 | | Vol. 3.00 – 6 January, 2022 |
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| Scientists established iTracer, a lineage recorder that combined reporter barcodes with inducible CRISPR–Cas9 scarring and was compatible with single-cell and spatial transcriptomics.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that human alveolar type 2 cells (hAEC2s), unlike murine AEC2s, transdifferentiated into basal cells in response to fibrotic signaling in the lung mesenchyme, in vitro and in vivo.
[Nature Cell Biology] |
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| A proteome map of COVID-19 skin was established and the susceptibility of human-iPSC-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.
[Advanced Science] |
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| Scientists developed a new microfluidic multi-organoid system that recapitulated the human liver-pancreatic islet axis in normal and disease states.
[Advanced Science] |
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| Researchers generated human fallopian tube epithelial (FTE) organoids from BRCA1 mutation carriers that provided a faithful physiological in vitro model of FTE lesion generation and early carcinogenesis.
[Cell Reports] |
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| To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.
[Acta Physiologica] |
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| Biliary progenitor cells were isolated and grown as organoids from gallbladders. Cells and tissue were analyzed using histology, immunohistochemistry and Western blot assays.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.
[International Journal of Oncology] |
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| Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.
[Journal of Radiation Research] |
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| Organoids hold promise for the study of atypical cellular, molecular, and genetic features that underscore neurological diseases.
[Annual Review of Neuroscience] |
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| Investigators summarize available models as well as novel drug screening approaches, from simple to more advanced platforms.
[Drug Discovery Today] |
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| Brain organoids capture the developmental progression of the human brain and contain human-enriched progenitor cell types.
[Frontiers in Molecular Neuroscience] |
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| FUJIFILM Cellular Dynamics, Inc. and PhenoVista Biosciences announced a strategic alliance to improve the drug discovery process, by using iPSCs in screening.
[FUJIFILM Cellular Dynamics, Inc. (GlobeNewswire, Inc.)] |
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| Dr. Steven DeVries, a professor of Ophthalmology at the University of Wisconsin, has received an International Research Collaborators Award from Research to Prevent Blindnes that will allow him to learn from scientists at Ritsumeikan University in Japan about the process of growing 3D retinal organoids from stem cells.
[Ophthalmology Times] |
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January 21 -23, 2022
Austin, Texas, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Austrian Academy of Sciences – Vienna, Austria |
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| | Center for Genomic Regulation – Barcelona, Spain |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Washington University – St. Louis, Missouri, United States |
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