 | | Vol. 3.01 – 13 January, 2022 |
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| Scientists developed approaches for specifying the initial organoid geometry to build intestinal organoids of defined shape, size, and cell distributions, forming structures that were predictable, more similar to normal organs, and reproducible.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported a cyborg brain organoid platform, in which “tissue-like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids.
[Advanced Materials] |
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| Using wild-type and a trapping-deficient poly (ADP-ribose) polymerase (PARP1) mutant combined with rapid immunoprecipitation mass spectrometry of endogenous proteins and Apex2 proximity labeling, investigators delineated mass spectrometry-based interactomes of trapped and non-trapped PARP1.
[Nature Cell Biology] |
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| Investigators presented how to generate 3D spheroids resembling specific domains of the nervous system and then how to integrate them physically to allow axonal projections and synaptic assembly.
[Nature Protocols] |
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| Scientists reported gastric organoids established from tumor tissues comprising four signet ring cell carcinoma (SRCCs) and eight non-SRCCs.
[Cell Death Discovery] |
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| This analysis protocol utilized morphological image processing to identify cellular structures within each image and quantify their circularity and size. Using this script, time-lapse images of aggregating and non-aggregating culture conditions are analyzed to profile early changes in size and circularity.
[Scientific Reports] |
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| The authors assessed the effective interactions of mesenchymal stem cells and human embryonic stem cells during retinal organoid formation.
[Life Sciences] |
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| Researchers examined whether integration of allogeneic cell-based implants with the surrounding native cartilage could be demonstrated in an ex vivo human osteochondral culture model.
[Tissue Engineering Part C-Methods] |
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| Investigators developed a new method to generate 3D spatial-organized cardiac organoids from 2D micropatterned hiPSC colonies, instead of directly from 3D stem cell aggregates.
[Cell Tissues Organs] |
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| The authors discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.
[Stem Cell Research & Therapy] |
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| Scientists gather what is known about the impact of phenylalanine in the brain of patients and highlight where hiPSC-derived organoids could contribute to the understanding of this disease.
[Frontiers in Molecular Neuroscience] |
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| Prellis Biologics, Inc. announced that it has entered into a multi-target drug discovery collaboration and licensing agreement with Bristol Myers Squibb utilizing Prellis Biologics’ first-in-class externalized human immune system based on human lymph node organoids.
[Prellis Biologics, Inc. (Business Wire, Inc.)] |
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| Memorial Sloan Kettering Cancer Center (MSK) announced the launch of the Fiona and Stanley Druckenmiller Presidential Innovation Fund, which is intended to lead to new, more effective ways to treat and cure cancer by rapidly seeding the most promising projects in translational cancer medicine that might otherwise go unfunded.
[Memorial Sloan Kettering Cancer Center] |
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| February 2 – 6, 2022
Salt Lake City, Utah, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Austrian Academy of Sciences – Vienna, Austria |
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| | Center for Genomic Regulation – Barcelona, Spain |
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