 | | Vol. 3.02 – 20 January, 2022 |
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| Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported increased gasdermin B (GSDMB) in inflammatory bowel disease, with single-cell analysis identifying epithelial specificity to inflamed colonocytes/crypt top colonocytes.
[Cell] |
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| Researchers uncovered heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that were enriched in prostate cancer and identified a population of tumor-associated club cells that may be associated with prostate carcinogenesis.
[Nature Communications] |
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| Scientists developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
[Nature Communications] |
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| Researchers comprehensively illustrated the capacity of adeno-associated virus (AAV) vectors co-expressing a cocktail of three short hairpin RNAs directed against the SARS-CoV-2 RdRp and N genes as versatile and effective antivirals.
[Molecular Therapy] |
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| Investigators reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative capacity.
[Cell Reports] |
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| Scientists developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.
[Cell Reports] |
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| The authors analyzed the expression of 373 miRNAs and 12 deregulated metabolic genes in murine duodenal polyps and non-polyp-derived organoids.
[Oncogenesis] |
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| Investigators studied human iPSCs that had been expanded into a self-formed ectodermal autonomous multi-zone of cells that partially mimicked human eye development.
[Stem Cell Reports] |
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| Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.
[iScience] |
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| Scientists explore the mechanisms and detection of acute kidney injury in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models.
[Journal of the American Society of Nephrology] |
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| In a TCGA-melanoma dataset, tumor cellularity exhibited additive prognostic value in the immune score signature to predict overall survival in patients with early-stage melanoma.
[npj Precision Oncology] |
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| Keio University in Tokyo said it has started the world’s first clinical test using induced pluripotent stem cells, or iPS cells, to treat patients with spinal cord injuries.
[Kyodo News] |
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| The Michael J. Fox Foundation has awarded three new grants totaling $5.2 million to Arizona State University to explore three pioneering treatments for Parkinson’s disease.
[Arizona State University] |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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