 | | Vol. 3.03 – 27 January, 2022 |
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| Scientists presented a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visuality.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a long-term culture of human fetal thyroid organoids system, which retained the fetal thyroid lineages and molecular signatures, as well as the ability to generate functional human thyroid follicles post mice renal transplantation.
[Advanced Science] |
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| Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells promote cancer cell proliferation and tumor growth.
[Science Advances] |
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| The authors comprehensively dissected genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unraveled distinct transcriptional programs enriched in brain metastasis.
[Nature Communications] |
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| Investigators compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain.
[American Journal of Human Genetics] |
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| Researchers extended the transcriptomic analyses to incorporate single-cell assay for transposase-accessible chromatin sequencing (ATAC-seq), a powerful method used to characterize potential gene regulatory networks through the changes in accessible chromatin that accompany cell-state changes.
[Cell Reports] |
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| The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.
[Oncogene] |
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| Scientists developed an organoid-based 3D culture model to recapitulate key features of fatty liver disease focusing on intracellular lipid accumulation and metabolic dysregulation.
[Journal of Molecular Medicine] |
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| Investigators described a simple method to generate organoid cultures using isolated human tracheobronchial epithelial cells grown in mixed matrix components and supplemented at day 14 with the Wnt pathway agonist R-spondin 2 and the bone morphogenic protein antagonist Noggin.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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Researchers presented novel biocompatible Polydimethylsiloxane-based micromechanical tweezers capable of the stiffness characterization and manipulation of hydrogel-based organoids.
[PLoS One] |
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| Scaffold-based 3D culture systems and organoids provide greater microenvironmental complexity but do not replicate fluid flows and dynamic responses to fluidic stimuli.
[Nature Reviews Nephrology] |
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| The auhthors showed that TNF-independent intestinal epithelial cell death after A20 and Abin-1 deletion was rescued by germ-free derivation or deletion of MyD88, while deletion of Trif provided only partial protection.
[Journal of Clinical Investigation] |
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| Investigators discuss available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based 2D models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.
[Stem Cell Reports] |
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| Pluristyx, Inc., panCELLa, and Implant Therapeutics announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation of safe, universal, cost-effective, “off-the-shelf” iPSCs.
[Pluristyx, Inc.] |
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| EsoCap announced that the company entered into a worldwide, exclusive antibody licensing agreement with Upadia, to develop targeted therapeutics to treat Barrett’s esophagus.
[EsoCap] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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