 | | Vol. 3.05 – 10 February, 2022 |
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| The authors provided a reproducible protocol to robustly induce intestinal morphogenesis in a microfluidic gut-on-a-chip as well as in a Transwell-embedded hybrid chip.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple negative breast cancers stem cells.
[Clinical Cancer Research] |
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| By leveraging recent knowledge of the signaling pathways involved in liver development, researchers described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.
[Stem Cell Reports] |
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| Researchers found that combining p110β with RAC/PAK1 or tankyrase inhibitors significantly reduced the growth of murine and human CRPC organoids in vitro and in vivo.
[Molecular Cancer Research] |
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| Investigators isolated primary alveolar type-2 cells (AEC2) from patient-derived lung tissues including those from patients with severe emphysema, using magnetic bead-based selection of cells expressing the AEC2 marker HTII-280.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| Scientists used two forms of hiPSC-derived HMOX1-reporter renal organoids to probe their ability to detect nephrotoxicants in a panel of blind-coded compounds.
[iScience] |
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| Using iPSC-derived kidney organoids, SARS-CoV-1, SARS-CoV-2 and MERS-CoV tropism, defined by the paired expression of a host receptor and protease, was identified primarily amongst proximal tubule cells.
[iScience] |
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| Using hiPSC-derived retinal organoids, the authors identified the time-dependent role of mammalian target of rapamycin complex 1 (mTORC1) in retinal development, specifically in retinal ganglion cell differentiation and the retinal lamination process, during the early stages of retinal organoid development.
[Cell Death Discovery] |
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| Researchers established motor nerve organoids from human PSCs with properties similar to those of neuromesodermal progenitors, a population of progenitor cells that comprise the caudal spinal cord.
[Scientific Reports] |
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| As methods to culture lung cancer organoids increase in sophistication, this model will undoubtedly stand its ground in the coming years in every aspect of cancer researches, especially with major advantages in the field of personalized medicine and tumor microenvironment researches.
[Critical Reviews in Oncology/Hematology] |
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| Scientists explored the evolving evidence that specific bile acid metabolites interact with intestinal epithelial and immune cells to contribute to the inflammatory milieu seen in inflammatory bowel disease.
[Frontiers in Immunology] |
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| SEngine Precision Medicine, Inc. and Oncodesign announced the signature of a research collaboration agreement for R&D of a new personalized cancer treatment for aggressive and untreatable tumors.
[SEngine Precision Medicine, Inc. (Globe Newswire, Inc.)] |
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| Dr. Josef Penninger and School of Biomedical Engineering (SBME) researchers Dr. Nozomu Yachie, and Dr. Nika Shakiba were recognized as Allen Distinguished Investigators, who have been funded to lead a project that traces the “family trees” of individual stem cells as they grow and divide into organoids.
[The University of British Columbia] |
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| The Paul G. Allen Frontiers Group, a division of the Allen Institute, announced 11 awards of $1.3-1.5 million each to fund research projects led by 23 new Allen Distinguished Investigators.
[Allen Institute] |
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| April 3 – 6, 2022
Warwick, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | IRB Barcelona – Barcelona, Spain |
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| | King’s College London- London, England, United Kingdom |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | King’s College London- London, England, United Kingdom |
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