 | | Vol. 3.07 – 24 February, 2022 |
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| Scientists developed an expansion microscopy method termed PhASE-ExM, enabling optical clearance and super-resolution imaging of organoids and their extracellular matrix in 3D.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using patient-derived ectocervical organoids, researchers systematically modeled individual and coinfection dynamics of human papillomavirus (HPV)16 E6E7 and Chlamydia, associated with carcinogenesis.
[Nature Communications] |
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| DevKidCC was used to directly compare between distinct kidney organoid protocols, identifying differences in relative proportions of cell types at all hierarchical levels of the model.
[Genome Medicine] |
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| Scientists showed that pharmacological RUNX1 inhibition significantly blocks tumor growth in vivo and in primary patient-derived PDAC organoids.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators reported a medium-throughput drug-screening platform based on organotypic cultures that allowed the evaluation of inhibitors against metastases growing in situ.
[EMBO Molecular Medicine] |
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| Researchers designed a user-friendly microfluidic device to generate hydrogel microspheres with sharp needles that could be replaced at will.
[Biofabrication] |
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| Scientists described the optimization of the first lead chromodomain helicase DNA-binding protein 1 like (CHD1L) inhibitors through drug design and medicinal chemistry.
[Journal of Medicinal Chemistry] |
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| The authors found that hemin-treated kidney organoids showed oxidative damage, increased expression of injury markers, impaired functionality of organic anion and cation transport and underwent fibrosis.
[Stem Cell Research & Therapy] |
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| A 3D organoid bioassay was utilized to test the efficacy of the combination therapy in a panel of seven epithelial ovarian cancer cell lines and ten platinum‑resistant primary patient tumor samples.
[International Journal of Oncology] |
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| Researchers reported a bank of human patient-derived xenografts and matched organoid cultures from tumors that represented the greatest unmet need: endocrine-resistant, treatment-refractory, and metastatic breast cancers.
[Nature Cancer] |
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| The authors discuss whether kidney organoids and tubuloids are suitable models for the study of complex human kidney disease and highlights their advantages and limitations compared with monolayer cell culture and animal models.
[American Journal of Pathology] |
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| The development, applications, strengths, and challenges of patient-derived models in cancer research are characterized.
[World Journal of Surgical Oncology] |
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| A newly launched startup is building upon innovations developed over several years at the Wyss Institute, Harvard John A. Paulson School of Engineering & Applied Sciences, and Brigham and Women’s Hospital to engineer functional kidney tissue for renal repair and replacement therapy.
[Wyss Institute] |
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| Clarkson University Assistant Professor of Chemical & Biomolecular Engineering Bethany Almeida has received a $200,000 National Science Foundation (NSF) Engineering Research Initiation grant.
[Clarkson University] |
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| 6 – 9 March, 2022
EMBL Heidelberg and Virtual |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | University of Lausanne – Lausanne, Switzerland |
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| | University Of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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