Organoid News Volume 3.09 | Mar 10 2022

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    2022-03-10 | ON 3.09


    Organoid News by STEMCELL Technologies
    Vol. 3.09 – 10 March, 2022
    TOP STORY

    Emerging Enterococcus Pore-Forming Toxins with MHC/HLA-I as Receptors

    Scientists identified a family of Enterococcus pore-forming toxins in E. faecalis, E. faecium, and E. hirae strains isolated across the globe.
    [Cell]

    Full Article
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Lactobacillus murinus Alleviate Intestinal Ischemia/Reperfusion Injury through Promoting the Release of Interleukin-10 from M2 Macrophages via Toll-Like Receptor 2 Signaling

    A transwell co-culture system of small intestinal organoids extracted from control mice and macrophages extracted from control mice or Toll-like receptor 2 (TLR2)-deficient mice or interleukin-10-deficient mice were established separately to explore the potential mechanism of reducing intestinal ischemia/reperfusion injury.
    [Microbiome]

    Full Article

    An Organoid Model of Colorectal Circulating Tumor Cells with Stem Cell Features, Hybrid EMT State and Distinctive Therapy Response Profile

    Investigators generated organoids from circulating tumor cells isolated from an orthotopic colorectal cancer xenograft model.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Disruption of the Crypt Niche Promotes Outgrowth of Mutated Colorectal Tumor Stem Cells

    While azoxymethane delivery in vivo under non-adenoma-forming conditions yielded phenotypically normal mucosa and organoids derived thereof, niche injury ex vivo by progressive DSS dose escalation facilitated outgrowth of Wnt-independent dysplastic organoids.
    [JCI Insight]

    Full Article

    Microglia Integration into Human Midbrain Organoids Leads to Increased Neuronal Maturation and Functionality

    Researchers described an approach to derive microglia from hiPSCs and integrated them into iPSC-derived midbrain organoids.
    [Glia]

    Full Article

    Milk-Derived Small Extracellular Vesicles Promote Recovery of Intestinal Damage by Accelerating Intestinal Stem Cell-Mediated Epithelial Regeneration

    Intestinal organoids and mice were used to explore the effects of milk-derived small extracellular vesicles on intestinal regeneration.
    [Molecular Nutrition & Food Research]

    Abstract

    Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

    Human intestinal organoids expressed core mitochondrial and ECM genes and enriched biologic functions implicated in Crohn’s disease ileal strictures; ECM gene expression was suppressed by both butyrate and eicosatetraynoic acid, with butyrate also suppressing genes regulating epithelial proliferation.
    [Inflammatory Bowel Diseases]

    Abstract

    Alternative Medicine: Therapeutic Effects on Gastric Original Signet Ring Carcinoma via Ascorbate and Combination with Sodium Alpha Lipoate

    Two natural supplements, ascorbate and sodium alpha lipoat, in a series of combinations were incubated with non-signet ring cell carcinoma (SRCC) cells, patient-derived gastric origin SRCC, gastric-origin SRCCs, human pancreatic and ovarian cells for evaluating their therapeutic effects.
    [BMC Complementary and Alternative Medicine]

    Full Article

    Mucin Distribution in Bronchiolar Adenoma/Ciliated Muconodular Papillary Tumor Reveals Organoid Differentiation Simulating the Normal Lung

    Investigators evaluated the distribution of MUC5AC and MUC5B in bronchiolar adenoma/ciliated muconodular papillary tumors for comparison with that seen in normal respiratory tracts.
    [Pathology International]

    Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Probing Single Ventricle Heart Defects with Patient-Derived Induced Pluripotent Stem Cells and Emerging Technologies

    The authors present recent approaches and findings utilizing patient-specific iPSCs to identify cellular mechanisms responsible for improper cardiac organogenesis in hypoplastic left heart syndrome and hypoplastic right heart syndrome.
    [Birth Defects Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cincinnati Children’s Hospital Medical Center and Orange Grove Bio Establish Collaboration to Develop and Commercialize Novel Therapeutics

    Orange Grove Bio and Cincinnati Children’s Hospital Medical Center announced the establishment of a collaboration designed to advance the development and commercialization of novel therapeutics by supporting the translation of scientific discoveries made by researchers at Cincinnati Children’s.
    [Orange Grove Bio (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting

    April 7 – April 9, 2022
    Rome, Italy & Virtual
    JOB OPPORTUNITIES

    Research Assistant – Gut-on-a-Chip Organoids

    University of Copenhagen – Copenhagen, Denmark

    Scientist – Organoid Models

    Frederick National Laboratory – Frederick, Maryland, United States

    Research Technician – Placental Development

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Postdoctoral Position – Tissue Engineering and Epigenetics

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Fellow – Breast Cancer Organoids

    Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States

    > See All Jobs

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