 | | Vol. 3.10 – 17 March, 2022 |
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| The authors reported that iPSCs reprogramed from CD62L+ naive and memory T cells followed by CD19-chimeric antigen receptor engineering and 3D-organoid system differentiation conferred products with conventional CD8αβ-positive CAR T cell characteristics.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To gain insights into the pharmacobiology of human colorectal cancer, investigators created a robust drug screening platform for patient-derived colorectal organoids.
[Nature Chemical Biology] |
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| Scientists developed an implantation-on-a-chip that was capable of reconstructing the 3D structural organization of the maternal-fetal interface to model the invasion of specialized fetal extravillous trophoblasts into the maternal uterus.
[Nature Communications] |
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| The basal layer cells of tonsil epithelial cell–derived organoids expressed molecules essential for SARS-CoV-2 entry, such as angiotensin-converting enzyme 2, transmembrane serine protease 2 and furin, being susceptible to the viral infection.
[Biomaterials] |
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| Researchers showed that β-catenin stabilization, when targeted to either the mammary luminal or basal epithelial lineage, led to cellular rearrangements that precipitates the formation of hyperplastic lesions that underqwnt squamous transdifferentiation.
[Cell Reports] |
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| Scientists used cerebral organoids derived from patients and genome edited-iPSCs to address pathophysiological changes associated with a complex malformation of human cortical development caused by mutations in the echinoderm microtubule-associated protein-like 1 (EML1) gene.
[EMBO Reports] |
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| Investigators suggested that micro-computed tomography (CT) analyzable PSC-derived alveolar human lung organoids were a promising in vitro model to predict lung toxicity manifestations, including fibrosis.
[Cell Biology and Toxicology] |
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Researchers described an approach to derive microglia from human iPSCs and integrated them into iPSC-derived midbrain organoids.
[Glia] |
| | Whole brain organoids were created from induced pluripotent stem cells from healthy individuals and individuals suffering from autism.
[Journal of Neural Transmission] |
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| The authors sought to measure respiratory syncytial virus (RSV) replication, cytopathic effects, and protein expression in human lung organoids reproducing architecture and transcriptional profiles of human fetal lungs during the first trimester of gestation.
[PLoS One] |
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| Scientists identify the major bottlenecks preventing patient-derived tumour organoids (PDTOs) from being used in clinical setting. Unsuitable methods of tissue acquisition, disparities in establishment rates and a lengthy timeline are the limiting factors for use of PDTOs in clinical application.
[Biomarker Research] |
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| Promega Corporation and FUJIFILM Cellular Dynamics, Inc., a leading global developer and manufacturer of human iPSC technologies, announced a strategic collaboration to advance novel assay development for drug discovery.
[Promega Corporation] |
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| A Saint Louis University (SLU) School of Medicine physician-scientist has received funding from the National Institutes of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to study Short Bowel Syndrome.
[Saint Louis University] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Frederick National Laboratory – Frederick, Maryland, United States |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | Cold Spring Harbor Laboratory – Cold Spring Harbor, New York, United States |
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