 | | Vol. 3.11 – 24 March, 2022 |
| |
|
|
| The authors showed that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation could be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells.
[Nature Biomedical Engineering] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.
[Nature Biomedical Engineering] |
|
|
|
| An hiPSC-derived epithelial and mesenchymal organoid model in a 3D culture system for localized scleroderma therapy was established.
[Advanced Science] |
|
|
|
| Investigators developed in vitro methods using a kidney decellularized extracellular matrix hydrogel to culture hPSC-derived kidney organoids, which had extensive vascular network and their own endothelial cells.
[Advanced Science] |
|
|
|
| Researchers proposed a nanofibrillar hydrogel for the initiation and growth of breast cancer patient-derived tumor organoids.
[Nature Communications] |
|
|
|
| To better characterize human retinal cis-regulatory elements, investigators performed single-nucleus assay for transposase-accessible chromatin sequencing and single-nucleus RNA sequencing on the developing and adult human retina and on iPSC-derived retinal organoids.
[Developmental Cell] |
|
|
|
| Scientists determined the impact of human cytomegalovirus infection on the transcriptome of developing neurons in an organoid model system. Cell populations were isolated from organoids based on a marker for infection and transcriptomes were defined.
[iScience] |
|
|
|
| The authors designed a workflow to reproducibly extract proteins from brain organoids, measure global turnover using mass spectrometry, and statistically investigate turnover differences between genotypes.
[Methods] |
|
|
|
| Investigators described the development and implementation of a regressive deep learning model trained on brightfield images of patient-derived organoids and use the terminal viability readout as training labels.
[Slas Discovery] |
|  |
|
|
|
| Scientists review discuss the application of organ-on-chip platforms integrated with conventional 2D cell lines, 3D organoids and spheroid models, and the organotypic tissue slices, including patient-derived and xenograft tumor slice cultures in cancer treatment responses.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
|
|
|
| Investigators provide a brief overview of protocols that have laid the foundation for derivation of stem cell-derived 3D cardiac models.
[BMC Cardiovascular Disorders] |
|
|
|
|
| A $5 million gift from the Alfred E. Mann Family Foundation will help ensure that promising University of California, Los Angeles research on new treatments for diseases and innovative biomedical devices can advance from the lab to clinical settings.
[University of California, Los Angeles] |
|
|
|
| A Mount Sinai researcher has been awarded a five-year, $2.2 million grant from the National Institutes of Health (NIH) to expand skeletal muscle stem cells in culture, work that could someday be used to treat skeletal muscle injuries, sarcopenia, muscular dystrophy, and other muscle injuries and disorders.
[Mount Sinai] |
|
|
|
|
| April 8 – 13, 2022
New Orleans, Louisiana, United States |
|
|
|
|
|
| | University of Barcelona – Barcelona, Spain |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Mayo Clinic – Jacksonville, Florida, United States |
|
|
|
| | CRUK Manchester Institute – Manchester, United Kingdom |
|
|
|
| | Genentech, Inc. – South San Francisco, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
