 | | Vol. 3.12 – 31 March, 2022 |
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In a non-human primate model of lung injury, along with human organoids and tissue specimens, scientists showed that alveolar type-2 cells in regenerating lungs transiently acquired an alveolar type-0 state from which they could differentiate into either alveolar type-1 cells or respiratory bronchiole-secretory cells.
[Nature] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.
[Science Translational Medicine] |
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| Tthe culture and expansion of human cholangiocyte organoids in liver extracellular matrix-derived hydrogels is described. These hydrogels supported proliferation of cholangiocyte organoids and maintain the cholangiocyte-like phenotype.
[Biomaterials] |
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| Researchers demonstrated that gastrointestinal tissue-derived extracellular matrix hydrogels were suitable substitutes for Matrigel in gastrointestinal organoid culture.
[Nature Communications] |
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| The authors microinjected mouse spermatogonial stem cells into embryonic gonads or reaggregated neonatal testis organoids, which were transplanted under the tunica albuginea of mature testes.
[Stem Cell Reports] |
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| Using new protocols for hPSC-derived retinal organoid culture, scientists demonstrated improved outer segment formation for both rod and cone photoreceptors, including organized stacked discs.
[Stem Cell Reports] |
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| Researchers used human forebrain organoids, in vitro derived 3D cell cultures that recapitulated key human brain developmental features.
[Translational Psychiatry] |
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| The authors developed a tumor-chip device engineered to mimic the pancreatic ductal adenocarcinoma tumor microenvironment by incorporating patient-derived organoids and stromal cells, specifically pancreatic stellate cells and macrophages.
[Microsystems & Nanoengineering] |
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| Investigators described an analysis of nearly 3500 individual mouse-derived cancer organoids where individual organoid morphologic tracking was performed.
[Scientific Reports] |
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| The author review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host–microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and infectious pathogens.
[Nature Reviews Genetics] |
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| Scientists provide a comprehensive summary of fetal brain metabolic studies related to drug abuse in animal and human models.
[Frontiers in Neuroscience] |
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| Investigators review existing strategies for fabricating and incorporating vascular elements and perfusion within tissue organoids.
[Mammalian Genome] |
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| Vyant Bio, Inc. and OrganoTherapeutics announced they have entered into a collaboration agreement to work toward accelerating the discovery of drugs for the treatment of Parkinson’s Disease.
[Vyant Bio, Inc.] |
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| May 3 – 5, 2022
Berlin, Germany |
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| | The Hospital for Sick Children – Toronto, Ontario, Canada |
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| | The Wellcome Trust – London, England, United Kingdom |
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| | University of Barcelona – Barcelona, Spain |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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Cancer Stem Cell News
Cell Therapy News
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Extracellular Matrix News
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Intestinal Cell News
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Neural Cell News
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Pancreatic Cell News
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