 | | Vol. 3.13 – 7 April, 2022 |
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| Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators systematically dissected pancreatic ductal adenocarcinoma intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.
[Nature Communications] |
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| Scientists reported Fourier light-field microscopy using a hybrid point-spread function for fast, volumetric, and high-resolution imaging of entire organoids.
[Biosensors & Bioelectronics] |
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| To obtain a better appreciation of the molecular processes during the differentiation of iPSCs into hepatocytes, researchers employed a quantitative proteomic approach to follow the expression of 9,000 proteins, 12,000 phosphorylation sites, and 800 acetylation sites over time.
[Cell Reports] |
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| The authors found that chromodomain helicase DNA-binding 8 (CHD8) haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yielded symmetrically opposite expansions in their proportions.
[Cell Reports] |
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| Researchers constructed colorectal cancer PDOs and selected the Kruppel-like factor 5 (KLF5) inhibitor ML264 as the research object based on the results of an in vitro drug screening assay.
[Cell Death & Disease] |
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| Viral infection is one of the risk factors for Alzheimer’s disease (AD), and scientists demonstrated that Zika virus nfection in brain organoids could trigger AD pathological features, including β-amyloid and phosphorylated-Tau expression.
[Cell Death Discovery] |
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| To explore a role for reflux-induced epithelial-mesenchymal plasticity (EMP) in Barrett’s esophagus, investigators established and characterized human Barrett’s organoids, and sought evidence of EMP after treatment with acidic bile salts
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Small intestinal organoids were used to assess if arsenic exposure would impair intestinal stem cell differentiation.
[Toxicology Letters] |
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| Investigators discuss the role of epigenetic and metabolic dysregulations and their cross-talk in tumorigenesis with a special focus on gliomagenesis.
[Open Biology] |
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| The authors discuss the advantages and limitations of existing in vivo and in vitro models of Helicobacter pylori (H. pylori) infection, and how gastric organoids have been applied to study H. pylori pathogenesis.
[Helicobacter] |
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| Canada’s Stem Cell Network announced the launch of IGNITE 2022-2025, its three-year strategic plan funded by the Government of Canada through a $45 million Budget 2021 commitment, starting April 1st, 2022.
[Stem Cell Network] |
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| June 12 – 17, 2022
New London, New Hampshire, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The Hospital for Sick Children – Toronto, Ontario, Canada |
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| | The Wellcome Trust – London, England, United Kingdom |
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| | University of Barcelona – Barcelona, Spain |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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