Organoid News Volume 3.14 | Apr 14 2022

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    2022-03-14 | ON 3.14


    Organoid News by STEMCELL Technologies
    Vol. 3.14 – 14 April, 2022
    TOP STORY

    Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

    Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.
    [Cancer Research]

    Abstract
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    Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

    To identify the integrin adhesion systems that operate in PDAC, the authors analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.
    [Matrix Biology]

    Full Article

    Mesenchymal and Stem-Like Prostate Cancer Linked to Therapy-Induced Lineage Plasticity and Metastasis

    Researchers defined mesenchymal and stem-like prostate cancer, tracd its origin to therapy-induced lineage plasticity, and revealed its sensitivity to HER2/3 inhibition.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Spontaneous Activity of the Mitochondrial Apoptosis Pathway Drives Chromosomal Defects, the Appearance of Micronuclei and Cancer Metastasis through the Caspase-Activated DNAse

    Inhibition of mitochondrial apoptosis or of Caspase-activated DNAse reduced the number of micronuclei in tumor cell lines as well as the number of chromosomal misalignments in tumor cells and intestinal organoids.
    [Cell Death & Disease]

    Full Article

    Acquisition of NOTCH Dependence Is a Hallmark of Human Intestinal Stem Cell Maturation

    Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.
    [Stem Cell Reports]

    Full Article

    Human Pluripotent Stem Cell-Derived Kidney Organoids for Personalized Congenital and Idiopathic Nephrotic Syndrome Modeling

    Next-generation podocytes in kidney organoids enabled personalized idiopathic nephrotic syndrome modeling as shown by activated slit diaphragm signaling and podocyte injury following protamine sulfate, and puromycin aminonucleoside treatment.
    [Development]

    Abstract

    Mutation in the CCAL1 Locus Accounts for Bidirectional Process of Human Subchondral Bone Turnover and Cartilage Mineralization

    OPG-XL was studied by human induced pluripotent stem cells expressing OPG-XL and two isogenic CRISPR/Cas9-corrected controls in cartilage and bone organoids.
    [Rheumatology]

    Abstract

    Patient-Derived Endometrial Organoids from MRKH Patients: Insight in Disease Causing Pathways

    Investigators developed long-term expandable organoid cultures from endometrium found in uterine rudiment horns of Mayer-Rokitansky-Küster-Hauser (MRKH) patients.
    [Disease Models & Mechanisms]

    Abstract

    Generation of Human Embryonic Stem Cell-Derived Lung Organoids

    This protocol describes how to generate lung organoids from human embryonic stem cells. Lung organoids form by self-assembly in Matrigel and contain lung epithelial cell types.
    [STAR Protocols]

    Abstract
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    REVIEWS

    Human Organoid Models to Study SARS-CoV-2 Infection

    Scientists overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development.
    [Nature Methods]

    Full Article

    Progress in Multicellular Human Cardiac Organoids for Clinical Applications

    The authors highlight the recent remarkable progress on multicellular cardiac organoids and review the current status for their practical applications.
    [Cell Stem Cell]

    Abstract

    Plumbing Our Organs: Lessons from Vascular Development to Instruct Lab Generated Tissues

    Scientists review what’s been learned from embryonic blood vessels and how this knowledge instructs our approaches to vascularize laboratory generated tissues, such as organoids.
    [Current Topics in Developmental Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Fukushima Medical University Aim to Accelerate Cancer Research by Contributing Their Patient Derived Organoids to the CancerTools.org Initiative

    CancerTools.org, the research tools arm of Cancer Research UK, and the Fukushima Medical University and Summit Pharmaceuticals International announced a new partnership to progress their shared mission of accelerating cancer research.
    [Fukushima Medical University (MarketScreener)]

    Press Release
    FEATURED EVENT

    ISSCR 2022 Annual Meeting

    June 15 – 18, 2022
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Studentship – 3D Breast Cancer Models

    Queensland University of Technology – Queensland, Australia

    Postdoctoral Fellowship – Bioinformatics in Organoid Development

    University of Oslo – Oslo, Norway

    Laboratory Technician – iPSC and Organoid Maintenance

    Harvard University – Cambridge, Massachusetts, United States

    Research Associate – Pluripotent Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Researchers – Lung Development, Cystic Fibrosis, and COVID-19

    The Hospital for Sick Children – Toronto, Ontario, Canada

    > See All Jobs

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