Organoid News Volume 3.15 | Apr 21 2022

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    2022-04-21 | ON 3.15


    Organoid News by STEMCELL Technologies
    Vol. 3.15 – 21 April, 2022
    TOP STORY

    Generation of 3D Lacrimal Gland Organoids from Human Pluripotent Stem Cells

    The authors identified cells with characteristics of lacrimal gland primordia that emerged in 2D eye-like organoids cultured from human PSCs.
    [Nature]

    Abstract
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    USP25 Promotes Pathological HIF-1-Driven Metabolic Reprogramming and Is a Potential Therapeutic Target in Pancreatic Cancer

    Scientists developed a deubiquitylating enzyme discovery pipeline, combining activity-based proteomics with a loss-of-function genetic screen in patient-derived pancreatic ductal adenocarcinoma organoids and murine genetic models.
    [Nature Communications]

    Full Article

    Single Cell Transcriptomic Analysis Reveals Cellular Diversity of Murine Esophageal Epithelium

    Scientists performed single cell RNA-sequencing of 44,679 murine esophageal epithelial, to identify 11 distinct cell populations as well as pathways alterations along the basal-superficial axis and in each individual population.
    [Nature Communications]

    Full Article

    Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

    The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Diesel Exhaust Particles Distort the Lung Epithelial Progenitors and Their Fibroblast Niche

    Researchers used lung organoids derived from co-culture of alveolar epithelial progenitors and fibroblasts to investigate the effect of diesel exhaust particles on the epithelial-mesenchymal signaling niche in the distal lung, which is essential for tissue repair.
    [Environmental Pollution]

    Full Article
    Graphical Abstract

    Establishment and Characterization of Equine Mammary Organoids Using a Method Translatable to Other Non-Traditional Model Species

    The authors established equine mammary organoids (EqMaOs) from cryopreserved mammary tissue, in which mammary tissue fragments were isolated and embedded into a 3D matrix to produce EqMaOs.
    [Development]

    Full Article

    GATA3 and MDM2 Are Synthetic Lethal in Estrogen Receptor-Positive Breast Cancers

    Depletion and pharmacological inhibition of MDM2 significantly impaired tumor growth in GATA3-deficient models in vitro, in vivo and in patient-derived organoids/xenograft harboring GATA3 somatic mutations.
    [Communications Biology]

    Full Article

    Lactate Promotes the Growth of Patient-Derived Organoids from Hepatopancreatobiliary Cancers via ENO1/HIF1α Pathway and Does Not Affect Their Drug Sensitivities

    Scientists attempted to determine the effect of lactate supplementation on the growth, genetic profiles and drug sensitivities of patient-derived organoids from hepatopancreatobiliary tumors.
    [Cell Death Discovery]

    Full Article

    Clinical Outcomes of EGFR+/METamp+ vs. EGFR+/METamp- Untreated Patients with Advanced Non-Small Cell Lung Cancer

    Survival rates were estimated by the Kaplan–Meier method with log-rank statistics. Lung cancer organoids were generated from patient-derived malignant pleural effusion to perform drug sensitivity assays.
    [Thoracic Cancer]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    EGFR Signaling Pathway as Therapeutic Target in Human Cancers

    Studies investigating the function of epidermal growth factor receptor in solid malignancies have revealed numerous ways how tumor cells dysregulate EGFR function.
    [Seminars in Cancer Biology]

    Abstract

    Preparation and Application of Taste Bud Organoids in Biomedicine towards Chemical Sensation Mechanisms

    Investigators give a systemic and comprehensive introduction to the preparation and application of taste bud organoids towards chemical sensing mechanisms.
    [Biotechnology and Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Manufacturing Stem Cells in Space

    Scientists at Cedars-Sinai are launching their expertise into space to see if they can elevate the next generation of stem cell and gene therapies by harnessing the near-zero gravity conditions of spaceflight.
    [Cedars Sinai]

    Press Release
    FEATURED EVENT

    ESMO Breast Cancer

    May 3 – 5, 2022
    Berlin, Germany

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    JOB OPPORTUNITIES

    Clinical Fellowship – Tumor Genomes

    Weill Cornell Medicine – Ithaca, New York, United States

    Research Assistant – Organoids

    University of Singapore – Singapore, Singapore

    Postdoctoral Fellow – Single-Cell Genomics of Human Development

    University of Gothenburg – Gothenburg, Sweden

    PhD Studentship – 3D Breast Cancer Models

    Queensland University of Technology – Queensland, Australia

    Postdoctoral Fellowship – Bioinformatics in Organoid Development

    University of Oslo – Oslo, Norway

    > See All Jobs

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