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| The authors proposed a new method that enabled the real-time assessment of kidney organoids derived from stem cells. When placed on a conductive surface, these organoids generated unique electrochemical signals at ≈0.3 V with intensities proportional to the amount of kidney-specific cell types.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the generation of human somitoids, organoids that periodically formed pairs of epithelial somite-like structures.
[Nature Communications] |
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| Investigators induced vessel and brain organoids respectively, and then fused two types of organoids together to obtain vascularized brain organoids.
[eLife] |
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| Utilizing both an in vitro model and samples from women at high risk for estrogen receptor negative breast cancer (ER− BC), researchers showed that lipid exposure engendered gene expression, signaling pathway activation, and histone marks associated with the development of ER− BC.
[npj Breast Cancer] |
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| LX2 cells could be activated by conditioned medium from non-alcoholic fatty liver disease-derived organoids, but not from hepatitis B virus livers, whereas this activation was blocked by a VEGFA antibody.
[Acta Pharmacologica Sinica] |
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| Scientists showed that their systems generated chamber-specific organoids comprising of the major cardiac cell types, and they used single cell RNA sequencing together with sample multiplexing to characterize the cells they generated.
[Communications Biology] |
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| Investigators showed organoids grown in suspension with minimal concentration of Matrigel and in the presence of a cocktail of growth factors regulating EGF and FGF signaling could recapitulate key epithelial layers of adult mammary gland.
[Scientific Reports] |
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| Patient-derived organoids were established from pancreatic tumor surgical specimens, and the mutations were examined using a panel sequence. Expression of markers was assessed by PCR, immunoblotting, and immunohistochemistry.
[BMC Cancer] |
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| The authors review recent progress and breakthroughs in the automation and high-throughput imaging of 3D culture models, which can be integrated with machine-learning tools to aid quantitative high-throughput screening for drug discovery and development.
[Trends in Pharmacological Sciences] |
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| Scientists discuss the pre-clinical model and different types of human organoids as models for the development of high throughput drug screening and also highlight how organoids are shaping the future of cancer research.
[Acta Histochemica] |
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| Accelerated Biosciences announced an agreement for Pluristyx, Inc. to provide iPSCs derived from human trophoblast stem cells procured under Good Tissue Practices for research evaluation.
[Accelerated Biosciences (BioSpace, Inc.)] |
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| June 26 – July 1, 2022
Waterville Valley, New Hampshire, United States |
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| | Hubrecht Organoid Technology – Utrecht, Netherlands |
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| Duke University – Durham, North Carolina, United States |
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| | New York University College of Dentistry – New York, New York, United States |
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| | University of Singapore – Singapore, Singapore |
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| | Harvard University – Cambridge, Massachusetts, United States |
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