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Stem-Cell-Derived Trophoblast Organoids Model Human Placental Development and Susceptibility to Emerging Pathogens | Researchers reported that trophoblast stem cells isolated from naive hPSCs could efficiently self-organize into 3D stem-cell-derived trophoblast organoids with a villous architecture similar to primary trophoblast organoids.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Human Branching Cholangiocyte Organoids Recapitulate Functional Bile Duct Formation | Single-cell transcriptomics and functional analysis showed high similarity to primary cholangiocytes, and importantly, the branching growth mimiced aspects of tubular development and was dependent on JAG1/NOTCH2 signaling.
[Cell Stem Cell] |
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p57Kip2 Imposes the Reserve Stem Cell State of Gastric Chief Cells | Scientists p57Kip2 as a molecular switch for the reserve stem cell state of chief cells in mice. During homeostasis, p57 was constantly expressed in chief cells but rapidly diminished after injury, followed by robust proliferation.
[Cell Stem Cell] |
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Paracrine Signaling between Intestinal Epithelial and Tumour Cells Induces a Regenerative Programme | Using mouse intestinal organoids, the authors uncovered a paracrine mechanism by which intestinal cancer cells reactivate fetal and regenerative YAP-associated transcriptional programmes in neighbouring wildtype epithelial cells, rendering them adapted to thrive in the tumor context.
[eLife] |
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Vertical Sleeve Gastrectomy Induces Enteroendocrine Cell Differentiation of Intestinal Stem Cells through Bile Acid Signaling | Researchers hypothesized that the vertical sleeve gastrectomy-induced increase in enteroendocrine cells was due to changes in intestinal differentiation driven by an increase in bile acid signaling through farnesoid X receptor.
[JCI Insight] |
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Differentiation of Brain and Retinal Organoids from Confluent Cultures of Pluripotent Stem Cells Connected by Nerve-Like Axonal Projections of Optic Origin | Investigators described a simple and economical protocol that reproducibly gave rise to the neural retina and cortical brain regions from confluent cultures of stem cells.
[Stem Cell Reports] |
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UHMK1 Aids Colorectal Cancer Cell Proliferation and Chemoresistance through Augmenting IL-6/STAT3 Signaling | Scientists demonstrated that UHMK1 was frequently upregulated in colorectal cancer samples compared with adjacent normal tissue and high expression of UHMK1 predicted poor outcomes.
[Cell Death & Disease] |
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SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells | Investigators found that depletion of IFITM2 strongly reduced viral RNA production by all “variants of concern” in the human epithelial lung cancer cell line Calu-3.
[Journal of Virology] |
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Buprenorphine Alters Microglia and Astrocytes Acutely Following Diffuse Traumatic Brain Injury |
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Researchers investigated the acute effects of the opioid analgesic buprenorphine on diffuse neuronal/glial pathology, neuroinflammation, cell damage, and systemic physiology.
[Scientific Reports] |
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Engineering Multiscale Structural Orders for High-Fidelity Embryoids and Organoids | The authors review recent progress in reconstructing multiscale structural orders in embryoids and organoids.
[Stem Cell Reports] |
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Cardiac Organoids: A 3D Technology for Modeling Heart Development and Disease | The authors discuss the recent advances in cardiac organoid technologies derived from human ESCs and hiPSCs, with a focus on the summary of methods for organoid generation.
[Stem Cell Reviews and Reports] |
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A Guide to the Organ-on-a-Chip | Scientists give an introduction to the aspects of organs-on-chips (OoCs) that need to be considered when developing an application-specific OoC.
[Nature Reviews Methods Primers] |
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University Of Colorado To Invest $200 Million In New Regenerative Medicine Institute | The University of Colorado Anschutz Medical Campus announced that it will make a $200 million investment over the next five years to create the Gates Institute, a research and treatment center that will focus on the development of new regenerative, cellular and gene therapies for a variety of serious illnesses.
[Forbes] |
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| June 19 – 24, 2022
Smithfield, Rhode Island, United States |
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| | Jülich Research Centre – Jülich, Germany |
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| | IGBMC – Illkirch-Graffenstaden, France |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Hubrecht Organoid Technology – Utrecht, Netherlands |
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| Duke University – Durham, North Carolina, United States |
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