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| Researchers used ATAC-seq, RNA-seq, and DNA sequencing to investigate 22 organoids, six patient-derived xenografts, and 12 cell lines.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Cerebral organoids derived from autism spectrum disorder patients were generated to capture critical time-points in the neuronal development, and metabolism and protein expression were investigated.
[Molecular Psychiatry] |
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| Investigators optimized targeted metabolomics in mouse and human organoid models in ex vivo primary culture. They then used stable isotope tracer analyses to identify the pathways that fuel citrate synthesis.
[Molecular Metabolism] |
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| Scientists explored the uncharacterized function of somatostatin signaling in human pluripotent stem cell-derived photoreceptor differentiation.
[Cell Proliferation] |
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| The Z-stack imaging technique was used for the imaging of 3D organoids to gather all the organoids’ maximum cross sections in one imaging.
[Stem Cell Research & Therapy] |
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| RNA-sequencing analyses of ALDHPositive colon cancer stem cells (CSCs) from colon cancer patient-derived organoids and xenografts showed CSCs to be enriched for neural development genes.
[iScience] |
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| The authors conducted infection experiments in bronchial organoids (BO) and an BO-derived air-liquid interface model using eight SARS-CoV-2 variants.
[Communications Biology] |
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| Investigators used advanced breast cancers (ABCs)-derived organoids as the ex vivo therapeutic platform to clarify the effectiveness of resveratrol against different ABC subtypes.
[Phytotherapy Research] |
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| Researchers assessed gene expression profiles in epididymides, predicted signaling pathways and developed a novel 3D cell culture method to assess the regulation of epididymal development in vitro.
[Cell and Tissue Research] |
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| The authors highlight some of the established methods and also some exciting novel perspectives on organoids in the fields of gastroenterology.
[Gut] |
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| Investigators review the brief history of testicular organoid (TO) generation and some major strategies for functional applications of TOs.
[Journal of Assisted Reproduction and Genetics] |
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| Oral and maxillofacial organoids, tiny tissues and organs derived from stem cells cultured through 3-d cell culture models, can fully summarize the cell tissue structure, physiological functions and biological characteristics of the source tissues in the body.
[Tissue Engineering and Regenerative Medicine] |
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| A team of Georgia Tech researchers has built a better system to quickly produce high-resolution 3D images in real-time, providing a quantitative analysis of organoids. Led by Coulter BME Assistant Professor Shu Jia, their custom-built microscope can reconstruct a comprehensive 3D representation with a single camera image.
[Georgia Institute of Technology] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Stem Cell Network – Ottawa, Ontario, Canada |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Plymouth – Plymouth, England, United Kingdom |
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