 | | Vol. 3.24 – 23 June, 2022 |
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| Spectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 ‘gain-of-function’ experiments were applied on infected human lung explants and adult stem cell-derived human lung organoids to correlate ACE2 and related host factors with SARS-CoV-2 tropism, propagation, virulence, and immune activation.
[European Respiratory Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Nanoparticles conjugated with the cytostatic drug doxorubicin and a fluorescent dye exhibited significantly greater cytotoxicity toward CT-26 tumor spheroids than equally concentrated dissolved doxorubicin.
[Small] |
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| The authors introduced a platform for routine grafting of liver and other tissues on an in vitro grown microvascular bed.
[Angiogenesis] |
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| Scientists established a framework to identify constraints on an organoid’s morphological features by quantifying them from microscopy images of organoids exposed to a range of perturbations.
[Cell Systems] |
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| Investigators constructed an airway organoid of Dnah9 knock-down mice and discovered that it could mimic the key features of the primary cilia dyskinesia (PCD) phenotypes.
[Cell Death & Disease] |
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| Researchers attempted to elucidate the events that result in carcinogenesis and identify the cancer cell-of-origin.
[Oncogenesis] |
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| In human pituitary tumors, cells typified by expression of stemness markers, in particular SOX2 and SOX9, were found present in a wide variety of clinical tumor types, also showing a pronounced proliferative status.
[Endocrine-Related Cancer] |
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| The authors reported that mucinous colorectal carcinoma tumors maintained a robust apico-basolateral polarity as they spread in the peritumoral stroma or organotypic collagen-I gels.
[Journal of Cell Science] |
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| Scientists isolated 15 single clones from four tumor organoid lines from one patient at a primary passage from one patient. Each organoid line showed variable alterations in both genotype and phenotype.
[Biomedicine & Pharmacotherapy] |
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| Investigators summarize the natural tissue and organ’s unique chemical and mechanical properties, guiding researchers to design an extracellular microenvironment used for organoid engineering
[Tissue Engineering Part B-Reviews] |
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| Israel’s first organoid bank was established at Hadassah University Medical Center in Ein Kerem. Organoids are used for medical research and translational medicine around the world.
[The Jerusalem Post] |
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| the family of Kimberly Greenberg and 1H-E Syndrome Foundation presented a $45,000 gift check to Dr. Jiang’s lab, which has succeeded on modeling H1-4 causing neurodevelopmental defects using human H1-4 patient derived iPSC and brain organoids.
[Yale School of Medicine] |
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| September 11 – September 16, 2022
Ventura, California, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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Cancer Stem Cell News
Cell Therapy News
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