|
| Using transcriptome and chromatin immunoprecipitation profiling of PDA cells treated with the MEK inhibitor, Trametinib (MEKi), researchers identified transcriptional antagonism between c-MYC and the master transcription factors for lysosome gene expression, the MiT/TFE proteins.
[Cancer Discovery] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators developed a novel approach for pharmacodynamic studies using transplanted, perfused human kidney organoids.
[Science Advances] |
|
|
|
| Colorectal cancer patient samples and samples from AOM/DSS treated mice were analyzed for expression of IL-9, CD3 and PU.1 by FACS analysis and immunohistochemistry.
[Journal of Crohn’s and Colitis] |
|
|
|
| The authors cerebral organoids derived from iPSCa were treated with 0.1 μg/mL or 0.5 μg/mL silver nanoparticles for seven days.
[Science of the Total Environment] |
|
|
|
| Researchers showed the knockout of β-arrestin 2 by CRISPR/Cas9 technology significantly weakened the Dopamine receptor D1 (DRD1)-induced proliferation and neurosphere growth.
[Stem Cells] |
|
|
|
| The authors established human airway organoids-based systems for seasonal coronavirus infection and to demonstrate their applications in studying virus-host interactions and therapeutic development.
[Ebiomedicine] |
|
|
|
| Scientists generated hiPSCs from three Leigh syndrome patient-derived fibroblast lines. Using whole-exome and mitochondrial sequencing, they identified unreported mutations in pyruvate dehydrogenase and dihydrolipoyl dehydrogenase.
[Development] |
|
|
|
| Investigators targeted nicotinamide phosphoribosyltransferase, a rate-limiting enzyme in the NAD+ synthesis salvage pathway, to observe its effect in the immune microenvironment.
[Journal of Cancer Research and Clinical Oncology] |
|
|
|
| Patient-derived organoids expand from highly proliferative LGR5+ tumor cells; however, scientists discovered that lack of optimal growth conditions specified a latent LGR5+ cell state.
[Nature Cancer] |
|  |
|
|
|
| Cerebral organoids have been shown to recapitulate the fetal brain gene expression profile, transcriptome, epigenome, as well as disease dynamics of both idiopathic and syndromic autism spectrum disorders.
[Gene Therapy] |
|
|
|
|
| A Mississippi State postdoctoral associate in the Department of Animal and Dairy Sciences is one of only 12 individuals nationwide being recognized with the 2022 Young Scholar Award from the American Society of Animal Science.
[Mississippi State University] |
|
|
|
|
|
|
|
| | University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| | European Molecular Biology Laboratory – Barcelona, Spain |
|
|
|
| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
|
|
|
| | Institute of Cancer Research – London, England, United Kingdom |
|
|
|
| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
