Organoid News Volume 3.27 | Jul 14 2022

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    2022-07-14 | ON 3.27


    Organoid News by STEMCELL Technologies
    Vol. 3.27 – 14 July, 2022
    TOP STORY

    Type-I-Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease

    Knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescued the down syndrome microglial phenotypes both during brain development and in response to pathological tau.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Webinar: The Promise of Organoid Medicine
    PUBLICATIONSRanked by the impact factor of the journal

    A Scalable Organoid Model of Human Autosomal Dominant Polycystic Kidney Disease for Disease Mechanism and Drug Discovery

    Researchers reported a modified human kidney organoid system that generated thousands of similar organoids, each consisting of one-two nephron-like structures.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Acetyl-CoA-Carboxylase 1-Mediated De Novo Fatty Acid Synthesis Sustains Lgr5+ Intestinal Stem Cell Function

    The authors reported that interfering with de novo FAS by deletion of the enzyme Acetyl-CoA-Carboxylase 1 inintestinal epithelial cells resulted in the loss of epithelial crypt structures and a specific decline in Lgr5+ intestinal epithelial stem cells.
    [Nature Communications]

    Full Article

    Renal Organoid Modeling of Tuberous Sclerosis Complex Reveals Lesion Features Arise from Diverse Developmental Processes

    Investigators reported a genetically engineered human renal organoid model that recapitulates pleiotropic features of tuberous sclerosis complex (TSC) kidney disease in vitro and upon orthotopic xenotransplantation.
    [Cell Reports]

    AbstractGraphical Abstract

    Hyaluronic Acid Methacrylate/Pancreatic Extracellular Matrix as a Potential 3D Printing Bioink for Constructing Islet Organoids

    Scientists developed a 3D-printed islet organoid by combining a pancreatic extracellular matrix and hyaluronic acid methacrylate as specific bioinks.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Microarrayed Human Bone Marrow Organoids for Modeling Blood Stem Cell Dynamics

    Researchers built a 3D in vitro model system of bone marrow (BM) organoids that recapitulated several structural and cellular components of native BM.
    [APL Bioengineering]

    Full Article

    Human Liver Organoids for Disease Modeling of Fibrolamellar Carcinoma

    The authors developed 21 patient-derived organoid lines: 12 from metastases, 3 from the liver tumor and 6 from adjacent non-tumor liver.
    [Stem Cell Reports]

    Full Article

    Engineering Rotating Apical-Out Airway Organoid for Assessing Respiratory Cilia Motility

    Scientists described a robust approach for reproducible engineering of apical-out airway organoid from a defined number of cells.
    [iScience]

    AbstractGraphical Abstract

    Resveratrol’s Neural Protective Effects for the Injured Embryoid Body and Cerebral Organoid

    Researchers induced human iPSCs to form the embryoid bodies and cerebral organoids with 3D culture.
    [BMC Pharmacology and Toxicology]

    Full Article
    Organoids: Experts Talk Standardization at Nature Research Round Table
    REVIEWS

    Ex Situ-Armus: Experimental Models for Combating Respiratory Dysfunction

    Investigators highlight recent studies, aided by ex situ systems, which have contributed to significant advances in our understanding of the human lower respiratory tract.
    [Current Opinion in Genetics & Development]

    Full Article
    INDUSTRY AND POLICY NEWS

    Academic-Industry Partnership Aims to Lower the Cost of Cultivated Meat

    Myo Palate is looking tap the synthetic biology expertise of Garton and his team in an effort to reduce the cost of growing muscle cells. The collaboration is funded by a grant provided jointly by Genome Ontario and the Canadian Food Innovation Network.
    [University of Toronto]

    Press Release
    FEATURED EVENT

    The Molecular Metabolism Conference: From Cell Biology to Systems Physiology

    August 7 – 11, 2022
    Treasure Drive, Nova Scotia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Associate – Intestinal Organoids

    Baylor College of Medicine – Houston, Texas, United States

    Technician – Cell Culture

    University of British Columbia – Vancouver, British Columbia, Canada

    Cell Biologist – Alzheimer’s Disease

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    > See All Jobs

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