Organoid News Volume 3.28 | Jul 21 2022

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    2022-07-21 | ON 3.28


    Organoid News by STEMCELL Technologies
    Vol. 3.28 – 21 July, 2022
    TOP STORY

    Near-Infrared-Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver

    A luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles, which were conjugated with antibody and rose bengal hexanoic acid was reported.
    [Advanced Science]

    Full Article
    Watch 'collaborating to accelerate COVID-19 research'
    PUBLICATIONSRanked by the impact factor of the journal

    Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

    Using primary human prostate organoids, investigators evaluated whether inhibiting an acK13-HOXB13 target, ACK1, with a selective inhibitor (R)-9b was superior to androgen receptor antagonists in inhibiting castration resistant prostate cancer growth.
    [Clinical Cancer Research]

    Abstract

    Development and Characterization of Human Fetal Female Reproductive Tract Organoids to Understand Müllerian Duct Anomalies

    Scientists developed organoids from human fetal fallopian tubes and uteri and compared them with their adult counterparts.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    KS10076, a Chelator for Redox-Active Metal Ions, Induces ROS-Mediated STAT3 Degradation in Autophagic Cell Death and Eliminates ALDH1+ Stem Cells

    Patient-derived organoid models demonstrated that KS10076 efficiently represses cancer cells with active KRAS, and fluorouracil resistance, which suggested clinical advantages.
    [Cell Reports]

    Abstract

    Mesenchymal-Epithelial Interaction Regulates Gastrointestinal Tract Development in Mouse Embryos

    Using the gut tube-derived organoids, the authors found that the cell fate of the foregut and hindgut could be switched by the regional niche factors, including fibroblast growth factors and retinoic acid.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Multifocal Organoids Reveal Clonal Associations between Synchronous Intestinal Tumors with Pervasive Heterogeneous Drug Responses

    Researchers reported one unique case of synchronous intestinal cancer with tumors occurring along the entire bowel tract, including the small intestine.
    [NPJ Genomic Medicine]

    Full Article

    Cucurbitane Triterpenoid Entities Derived from Hemsleya penxianensis Triggered Glioma Cell Apoptosis via ER Stress and MAPK Signaling Cross-Talk

    Scientists determined temozolomide-resistant GBM cell was the most sensitive to the tested compounds, and found hemsleyaoside N displayed the best antineoplastic potency.
    [Bioorganic Chemistry]

    AbstractGraphical Abstract

    Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies

    The authors used endoscopic ultrasound-guided fine-needle aspiration to collect pancreatic cancer tissues from patients with advanced pancreatic cancer to create organoids, and evaluated their utility in pancreatic cancer research.
    [Gut and Liver]

    Full Article

    Miniaturized and Multiplexed High-Content Screening of Drug and Immune Sensitivity in a Multichambered Microwell Chip

    Investigators established a framework for cell culture, formation of tumor spheroids, fluorescence labeling, and imaging of fixed or live cells at various magnifications directly in the chip together with data analysis and interpretation.
    [Cell Reports Methods]

    AbstractGraphical Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Human Organoids: New Strategies and Methods for Analyzing Human Development and Disease

    Scientists highlight novel advances in organoid biology with a focus on how organoid technology has generated a better understanding of human-specific processes in development and disease.
    [Cell]

    Abstract
    INDUSTRY AND POLICY NEWS

    Whitmer Axes Stem Cell Research, Pregnancy Center Funding over Abortion Access Concerns

    Governor Gretchen Whitmer used her veto pen on the state’s education budget Thursday to strike funding for pregnancy centers and stem cell research, saying that wording within the bill tried to “create a gag rule” concerning abortion.
    [Advance Local Media LLC]

    Press Release
    FEATURED EVENT

    The Gastrointestinal Tract XX Conference: Making and Breaking the Gut

    Aug 7 – 12, 2022
    Steamboat Springs, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant Professor – Cardiovascular and Regenerative Medicine

    Ohio State University Wexner Medical Center – Columbus, Ohio, United States

    Postdoctoral Scientists – Pluripotent Stem Cells and Developmental Biology

    Weill Cornell Medical College – New York, New York, United States

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Associate – Intestinal Organoids

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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