Organoid News Volume 3.29 | Jul 28 2022

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    2022-07-28 | ON 3.29


    Organoid News by STEMCELL Technologies
    Vol. 3.29 – 28 July, 2022
    TOP STORY

    Uncovering the Mode of Action of Engineered T Cells in Patient Cancer Organoids

    Scientists described a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means of imaging and transcriptomics.
    [Nature Biotechnology]

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    Transcriptomic and Proteomic Retinal Pigment Epithelium Signatures of Age-Related Macular Degeneration

    Transcriptomics and proteomics approaches identified molecular pathways significantly upregulated in geographic atrophy, including in mitochondrial functions, metabolic pathways and extracellular cellular matrix reorganization.
    [Nature Communications]

    Full ArticlePress Release

    Detergent Exposure Induces Epithelial Barrier Dysfunction and Eosinophilic Inflammation in the Esophagus

    Detergents, like sodium dodecyl sulfate, are common ingredients in household products like dish soap and toothpaste. Scientists hypothesized detergent exposure decreases epithelial barrier function and induces esophageal inflammation.
    [Allergy]

    Abstract

    Rapid and Robust Directed Differentiation of Mouse Epiblast Stem Cells into Definitive Endoderm and Forebrain Organoids

    The authors examined the potential of mouse epiblast stem cells cultured in media containing Wnt pathway inhibitors as a starting point for directed differentiation.
    [Development]

    Abstract

    Imaging Three-Dimensional Brain Organoid Architecture from Meso- to Nanoscale across Development

    Scientists developed a setup combining tissue expansion and light sheet fluorescence microscopy for imaging and quantifying diverse spatial parameters during organoid development.
    [Development]

    Abstract

    Organ-Specific Extracellular Matrix Directs Trans-Differentiation of Mesenchymal Stem Cells and Formation of Salivary Gland-Like Organoids In Vivo

    Rat bone marrow-mesenchymal stem cells were treated with homogenates of decellularized rat salivary gland-extracellular matrix for one hour in cell suspension and then cultured in tissue culture plates for seven days in growth media.
    [Stem Cell Research & Therapy]

    Abstract

    Production of Kidney Organoids Arranged around Single Ureteric Bud Trees, and Containing Endogenous Blood Vessels, Solely from Embryonic Stem Cells

    The authors developed a method for generating murine kidney organoids with improved higher-order structure, through stages using chimaeras of ex-fetu and PSC-derived cells to a system that works entirely from ESCs.
    [Scientific Reports]

    Full Article

    Establishment and Characterization of Human Pluripotent Stem Cells-Derived Brain Organoids to Model Cerebellar Diseases

    Brain organoids were characterized regarding brain development, cell type composition, and Machado-Joseph disease-associated neuropathology markers, to evaluate their value for cerebellar diseases modeling.
    [Scientific Reports]

    Full Article

    The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids

    Scientists assessed estrogen regulation of endometrial function by integrating the estrogen receptor alpha cistromes and transcriptomes of endometrial biopsies taken from the proliferative and mid-secretory phases of the menstrual cycle together with hormonally stimulated endometrial epithelial organoids.
    [Endocrinology]

    Abstract
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    REVIEWS

    Human Mini Brains and Spinal Cords in a Dish: Modeling Strategies, Current Challenges, and Prospective Advances

    Human mini brains are micro-scale physiological systems consisting of mixed populations of neural progenitor cells, glial cells, and neurons that may represent key features of human brain anatomy and function.
    [Journal of Tissue Engineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Lin and Greco Take Office as Leaders of Stem Cell Society

    Two of Yale’s stem cell faculty — Drs. Haifan Lin, and Valentina Greco— are serving in the highest ranks of the International Society for Stem Cell Research.
    [Yale School of Medicine]

    Press Release
    FEATURED EVENT

    The Neuro-Immune Axis

    September 11 – 13, 2022
    Lisbon, Portugal

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Biofabrication of 3D Bone Metastasis Model

    Warsaw University of Technology – Warsaw, Poland

    Research Associate – Pluripotent Stem Cells

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Assistant Professor – Cardiovascular and Regenerative Medicine

    Ohio State University Wexner Medical Center – Columbus, Ohio, United States

    Postdoctoral Scientists – Pluripotent Stem Cells and Developmental Biology

    Weill Cornell Medical College – New York, New York, United States

    Postdoctoral Researcher – Microfluidics, Organoids, and Precision Medicine

    Lehigh University – Bethlehem, Pennsylvania, Untied States

    > See All Jobs

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