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Vol. 3.30 – 4 August, 2022
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The authors reported the development of a human brain organoid microphysiological analysis platform to discover the dynamic process of immune-driven brain aging.
[Advanced Science]
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PUBLICATIONSRanked by the impact factor of the journal
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Researchers evaluated molnupiravir against variants of concern (VOC) in human airway epithelium organoids, ferrets, and a lethal Roborovski dwarf hamster model of severe COVID-19-like lung injury.
[Nature Communications]
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Mettl14 ablation triggered apoptosis that depleted Lgr5+ stem cells and disrupted colonic organoid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and organoids.
[Developmental Cell]
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Scientists defined and spatially mapped cell populations within the human ureter using single-cell RNA sequencing, spatial gene expression, and immunofluorescence approaches.
[Developmental Cell]
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The authors analyzed brain organoid and fetal single-cell RNA sequencing data from published and new datasets, totaling about 190,000 cells.
[EMBO Journal]
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Investigators described the generation of a collection of 19 pediatric rhabdomyosarcomas tumor organoid models comprising all major subtypes.
[EMBO Molecular Medicine]
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Researchers defined multiple pathways by which the gut microbiome protects mammalian hosts from SARS-CoV-2 intranasal infection, both locally and systemically, via production of short-chain fatty acids.
[Gut Microbes]
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The authors demonstrated label-free three-photon imaging of whole, uncleared intact organoids to assess early events of early human brain development.
[eLife]
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Researchers reported a method for simple, reproducible, and scalable production of small intestinal organoids based on the aggregation of cryopreservable human pluripotent stem cell (hPSC)-derived mid-hindgut endoderm monolayers.
[Stem Cell Reports]
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Scientists extended gastruloid culture conditions to capture features of embryonic blood development through a combination of immunophenotyping, detailed transcriptomics analysis, and identification of blood stem/progenitor cell potency.
[Scientific Reports]
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The authors review recent advances in synthetic morphogenesis, highlighting how a combination of microfabrication and mechanobiology is fostering our understanding of how tissues are built.
[Trends in Cell Biology]
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Clarkson University Biology Professor Kenneth Wallace was recently awarded a $429,000 grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development at the National Institute of Health (NIH) to investigate the development of intestinal stem cells using the zebrafish vertebrate model system.
[Clarkson University]
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Elena Daoutsali and Ronald Buijsen from the NeuroD research group were awarded the Sargenti Research Grant, organized by the Neuroscience Research Theme.
[NeuroD Lab]
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September 12 – 14, 2022
Liverpool, England, United Kingdom
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Nationwide Children’s Hospital – Columbus, Ohio, United States
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German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany
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Human Technopole – Milano, Italy
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Warsaw University of Technology – Warsaw, Poland
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The University of British Columbia – Vancouver, British Columbia, Canada
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