Organoid News Volume 3.31 | Aug 11 2022

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    2022-08-11 | ON 3.31


    Organoid News by STEMCELL Technologies
    Vol. 3.31 – 11 August, 2022
    TOP STORY

    Histone Deacetylase Inhibition by Gut Microbe-Generated Short Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms

    The authors cultured enteroids in media supplemented with sterile supernatants from the altered Schaedler Flora, a defined murine microbiota.
    [Gastroenterology]

    AbstractGraphical Abstract

    An ISSCR 2022 Innovation Showcase Webinar: Advances in GI Organoid Applications: Drug Discovery and Immunotherapy, presented by Dr. Ryan Conder. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Methylene Blue, Mycophenolic Acid, Posaconazole, and Niclosamide Inhibit SARS-CoV-2 Omicron Variant BA.1 Infection of Human Airway Epithelial Organoids

    Investigators demonstrated the susceptibility of the Omicron variant BA.1 to four repurposable drugs — Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide — in post-exposure treatments of primary human airway cell cultures.
    [Current Opinion in Microbiology]

    Full ArticleGraphical Abstract

    Medical Gas Plasma Augments Bladder Cancer Cell Toxicity in Preclinical Models and Patient-Derived Tumor Tissues

    Gas plasma treatment led to oxidation, growth retardation, motility inhibition, and cell death in 2D and 3D tumor models.
    [Journal of Advanced Research]

    Full ArticleGraphical Abstract

    Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants

    Scientists reported an organoid culture system of the nasal epithelium. They derived nasal organoids from easily accessible nasal epithelial cells with a perfect establishment rate.
    [mBio]

    Full Article

    The Uses of Transcriptomics and Lipidomics Indicated That Direct Contact with Graphene Oxide Altered Lipid Homeostasis through ER Stress in 3D Human Brain Organoids

    The authors used multi-omics techniques to investigate the mechanisms of graphene oxide on lipid homeostasis in a novel 3D brain organoid model.
    [Science of the Total Environment]

    AbstractGraphical Abstract

    AL101, a Gamma-Secretase Inhibitor, Has Potent Antitumor Activity against Adenoid Cystic Carcinoma with Activated NOTCH Signaling

    Researchers described the antitumor activity of osugacestat (AL101) using adenoid cystic carcinoma cell lines, organoids, and patient-derived xenograft models.
    [Cell Death & Disease]

    Full Article

    Direct Visualization of the Transition Status during Neural Differentiation by Dual-Fluorescent Reporter Human Pluripotent Stem Cells

    Investigators induced the differentiation of cortical neurons from dual-reporter human iPSCs, successfully visualizing cell-fate conversion in 2D culture and 3D organoids.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Androgen Receptor Variant-7 Regulation by Tenascin-C Induced Src Activation

    Utilizing heterotypical organoids, scientists showed that tenascin-C was C is an integral component of prostate cancer interaction with preosteoblasts.
    [Cell Communication and Signaling]

    Full Article

    Irradiation-Induced Intestinal Injury Is Associated with Disorders of Bile Acids Metabolism

    Investigators clarified the role of bile acid (BAs) metabolism in irradiation-induced intestinal injury and the potential for supplementation with BAs to alleviate intestinal injuries.
    [Radiation Oncology]

    Abstract
    ON1100CS-Wallchart Neural Stem Cells 728 x 90 A
    REVIEWS

    Bladder Cancer Patient-Derived Organoids and Avatars for Personalized Cancer Discovery

    The authors describe up-to-date organoid and xenograft models of bladder cancer created using patient-derived tissue.
    [European Urology]

    Abstract

    Advancing Preclinical Models of Psychiatric Disorders with Human Brain Organoid Cultures

    Advances in complexity of 3D cultures, recapitulating electrical activity in utero, and disease modeling of psychosis, mood, and environmentally induced disorders are reviewed.
    [Molecular Psychiatry]

    Full Article
    INDUSTRY AND POLICY NEWS

    Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors

    Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients.
    [Imaging Technology News]

    Press Release

    WITec Announces Paper Award 2022 Winners

    The WITec Paper Awards 2022 have been given to scientists from the US, Germany and China, recognizing their work in cement chemistry, pharmacy, and methane hydrate chemistry.
    [Oxford Instruments]

    Press Release
    FEATURED EVENT

    EHA Research Conference 2022

    October 17 – 20
    Palermo, Italy

    > See All Events

    JOB OPPORTUNITIES

    Senior Investigator – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Fellowship – Translational Cardiovascular Medicine

    University of Alberta – Edmonton, Alberta, Canada

    Professor and Canada Research Chair – Neurodevelopment

    University of Calgary – Calgary, Alberta, Canada

    Research Scientist – Functional Genomics Target Validation

    AstraZeneca – Cambridge, England, United Kingdom

    Postdoctoral Fellow – Ion Transport in the Kidney

    Radboud University – Nijmegen, The Netherlands

    > See All Jobs

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