 | | Vol. 3.39 – 6 October, 2022 |
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| Investigators developed Pando—a flexible framework that incorporates multi-omic data and predictions of transcription-factor-binding sites to infer a global gene regulatory network describing organoid development.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that the subset of intraepithelial lymphocytes that expressed γ and δ T cell receptor subunits promoted the viability of Paneth cells deficient in the Crohn’s disease susceptibility gene ATG16L1.
[Nature] |
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| Scientists present a comprehensive single-cell transcriptomic, epigenetic, and spatial atlas of human cortical organoid development, comprising over 610,000 cells, from generation of neural progenitors through production of differentiated neuronal and glial subtypes.
[Cell] |
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| Researchers defined the microglial responses to SARS-CoV-2 infection by single-cell transcriptomic profiling and observed an upregulation of interferon-responsive genes as well as genes promoting migration and synapse engulfment.
[Molecular Psychiatry] |
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| The authors showed that IL-22 regulated pro-inflammatory pathways were involved in microbial recognition, cancer and immune cell chemotaxis— most prominently those involving CXCR2+ neutrophils.
[Nature Communications] |
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| Researchers produced human telencephalic organoids from stem cell-derived single neural rosettes and investigated telencephalic development under normal and pathological conditions.
[Nature Communications] |
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| Investigators reporedt that H. pylori preferentially attached to differentiated cells in the pit region of gastric units. Single-cell RNA-seq showed that organoid-derived monolayers recapitulate the pit region, while organoids capture the gland region of the gastric units.
[Nature Communications] |
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| To determine mechanisms by which neutrophils, as early responders to bacterial challenge, direct inflammatory programming of human intestinal epithelium, scientists established a multi-component human intestinal organoid model of Salmonella enterica Typhimurium infection.
[PLoS Pathogens] |
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| Investigators generated iPSC-derived mesenchymal cells that had the ability to develop alveolar organoids with the aim of modeling niche environments and diseases.
[Cell Reports Methods] |
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| The authors discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments.
[Seminars in Cell & Developmental Biology] |
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| Scientists review models of human retinal disease, including animal models, and hPSC–derived models for their role in gene discovery and treatment of inherited retinal diseases.
[Retina-the Journal of Retinal and Vitreous Diseases] |
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| A research announcement to leverage the unique microgravity environment of the International Space Station for in-space production applications within the biomedical community is now open.
[ISS National Laboratory] |
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| Four young faculty members at Columbia University have received prestigious “New Innovator” awards from the NIH’s High-Risk, High-Reward program, including Dr. Christopher Makinson who is studying brain organoid maturation.
[Columbia University] |
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| Novemeber 17 – 18, 2022
Lisbon, Portugal |
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| | Aarhus University – Aarhus C, Denmark |
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| | University of Miami – Miami, Florida, United States |
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| | Syracuse University – Syracuse, New York, United States |
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| | NIH – Research Triangle Park, North Carolina, United States |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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