 | | Vol. 3.40 – 13 October, 2022 |
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| Scientists showed that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrated into sensory and motivation-related circuits.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported a hiPSC-based screening strategy to link human genetics with viral infectivity. A genome-wide association study identified a cluster of single-nucleotide polymorphisms in a cis-regulatory region of the NDUFA4 gene, which was associated with susceptibility to Zika virus infection.
[Cell Stem Cell] |
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| Scientists used human liver organoids in experimental systems to mimic the early stages of human liver carcinogenesis from the genetic lesions of TP53 loss and L3 loop R249S mutation.
[Hepatology] |
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| Investigators showed that enhanced specification to metanephric nephron progenitors results in elongated and radially aligned proximalised nephrons with distinct S1 – S3 proximal tubule cell types.
[Nature Communications] |
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| The authors reported a patient cohort with biallelic loss-of-function variants in KIF26A, exhibiting a spectrum of congenital brain malformations.
[Developmental Cell] |
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| Scientists described optimized conditions to continuously expand murine alveolar type 2 cells, a prominent cell of origin for lung adenocarcinoma, in organoid culture.
[Genes & Development] |
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| Investigators generated testicular organoids derived from testicular cells by combining hanging drop culture and rotation a culture system.
[Biofabrication] |
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| The authors induced inactivating deletions of CEP83 in hiPSCs and applied a 7 day in vitro protocol of intermediate mesoderm kidney progenitor differentiation, based on timed application of WNT and FGF agonists.
[eLife] |
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| Researchers generated retinal organoids from patient-derived iPS cells and gene-edited ESCs to model human IMPG2-retinitis pigmentosa in vitro.
[Stem Cell Reports] |
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| The authors review the history of the development of liver organoids and summarize the application of liver organoids and recent studies using organoids to explore and further repair the liver injury.
[Stem Cell Reviews and Reports] |
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| AIM Biotech, a Singapore- and Boston-based company, announced the launch of the organiX System—a lab tool to closely model human disease by adding vascularization and immune competence to organoids, spheroids, and tumor biopsies.
[Genetic Engineering & Biotechnology News] |
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| The Albanese Government is investing almost $7 million in Australia first stem cell research that will enable live stem cells to be 3D printed in order to treat damaged body parts.
[Commonwealth of Australia] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | Eindhoven University of Technology – Eindhoven, Netherlands |
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| | Institute of Tissue Regeneration Engineering – Cheonan, South Korea |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| | Aarhus University – Aarhus C, Denmark |
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| | University of Miami – Miami, Florida, United States |
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